RESUMO
BACKGROUND: To analyze the most common neurophthalmological conditions that may mimic glaucomatous optic neuropathy and to determine which most often lead to misdiagnosis when evaluated by a glaucoma specialist. METHODS: We reviewed the charts of consecutive patients with optic neuropathies caused by neurophthalmological conditions screened in a single Eye Clinic within a period of 24 months. Within these enrolled patients, we selected the eyes whose fundoscopic appearance could resemble glaucoma based in pre-defined criteria (vertical cup-to-disc ratio ≥0.6, asymmetry of the cup-to-disc ratio ≥0.2 between eyes, presence of localized retinal nerve fiber layer and/or neuroretinal rim defects, and disc haemorrhages). Then, color fundus photographs and Humphrey Visual Field tests (HVF) of these eyes were mixed with tests from 21 consecutive glaucomatous patients (42 eyes with normal tension glaucoma). These images were mixed randomly and a masked glaucoma specialist was asked to distinguish if each set of exams was from a patient with glaucoma or with a neurophthalmologic condition. RESULTS: Among the 101 eyes (68 patients) enrolled with neurophthalmological diseases, 16 (15.8%) were classified as conditions that could mimic glaucoma. The most common diagnoses were ischemic optic neuropathy (25%), compressive optic neuropathy (18.7%) and hereditary optic neuropathy (18.7%). Based on the analysis of fundus photographs and HVF tests, 25% of these were misdiagnosed as glaucoma (two ischemic optic neuropathies and two congenital optic disc anomalies). Conversely, 11.9% of the glaucomatous neuropathies were misdiagnosed as neurophthalmological disorders. Overall, the glaucoma specialist correctly diagnosed 84.5% of the eyes. CONCLUSIONS: Some neurophthalmological disorders can mimic glaucoma. In our study, isquemic and compressive optic neuropathies were the ones that most often did so. Almost one quarter of the eyes were misdiagnosed when evaluated by a glaucoma specialist, which can lead to inadequate management and influence the prognosis of these patients.
Assuntos
Erros de Diagnóstico , Glaucoma/diagnóstico , Doenças do Nervo Óptico/diagnóstico , Adulto , Idoso , Estudos Transversais , Diagnóstico Diferencial , Erros de Diagnóstico/estatística & dados numéricos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças do Nervo Óptico/patologia , Adulto JovemRESUMO
There is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease. Epidemiological data show that, cumulatively, optic neuritis is most frequently caused by many conditions other than multiple sclerosis. Worldwide, the cause and management of optic neuritis varies with geographical location, treatment availability, and ethnic background. We have developed diagnostic criteria for optic neuritis and a classification of optic neuritis subgroups. Our diagnostic criteria are based on clinical features that permit a diagnosis of possible optic neuritis; further paraclinical tests, utilising brain, orbital, and retinal imaging, together with antibody and other protein biomarker data, can lead to a diagnosis of definite optic neuritis. Paraclinical tests can also be applied retrospectively on stored samples and historical brain or retinal scans, which will be useful for future validation studies. Our criteria have the potential to reduce the risk of misdiagnosis, provide information on optic neuritis disease course that can guide future treatment trial design, and enable physicians to judge the likelihood of a need for long-term pharmacological management, which might differ according to optic neuritis subgroups.
Assuntos
Esclerose Múltipla , Neuromielite Óptica , Neurite Óptica , Humanos , Estudos Retrospectivos , Neurite Óptica/diagnóstico , Neuromielite Óptica/diagnóstico , Esclerose Múltipla/complicações , Autoanticorpos , Aquaporina 4RESUMO
A dolicoectasia da artéria carótida interna (ACI) é uma condição rara que pode ser acompanhada de manifestações neuro-oftalmológicas, como perda da acuidade e alteração do campo visual decorrente da compressão do nervo óptico (NO). O objetivo é relatar um caso de paciente do sexo masculino, 67 anos, portador de glaucoma primário de ângulo aberto (GPAA) com evolução atípica, assimetria de escavação, palidez da rima do NO à esquerda, devido à neuropatia óptica compressiva à esquerda, por segmento dolicoectásico da ACI. O diagnóstico foi baseado na história clínica, aspecto do NO e exames de neuroimagem.
Dolichoectasia of the internal carotid artery (ICA) is a rare condition that may be associated with neuro-ophthalmic manifestations, such as loss of visual acuity and visual field resulting from compression of the optic nerve (ON). The aim is to report a 67-year-old male patient with primary open-angle glaucoma (POAG) with atypical evolution, asymmetry of cupping and increased pallor of the rim of the left ON, due to compressive optic neuropathy by the dolichoectatic segment. The diagnosis was based on clinical history, appearance of the ON and neuroimaging.
Assuntos
Humanos , Masculino , Idoso , Transtornos da Visão/etiologia , Doenças das Artérias Carótidas/complicações , Doenças do Nervo Óptico/etiologia , Glaucoma de Ângulo Aberto/complicações , Síndromes de Compressão Nervosa/etiologia , Transtornos da Visão/diagnóstico por imagem , Imageamento por Ressonância Magnética , Doenças das Artérias Carótidas/diagnóstico por imagem , Artéria Carótida Interna/patologia , Artéria Carótida Interna/diagnóstico por imagem , Campos Visuais/fisiologia , Doenças do Nervo Óptico/diagnóstico por imagem , Angiografia por Ressonância Magnética , Pressão Intraocular/fisiologia , Síndromes de Compressão Nervosa/diagnóstico por imagemRESUMO
Este trabalho relata uma paciente de 52 anos que apresentou um paraganglioma orbitário, completamente removido através de uma orbitotomia lateral. Trata-se de um tumor benigno, bastante raro na órbita com apenas 28 casos previamente descritos. Nossa paciente apresentou uma lesäo com grande impregnaçäo de contraste à tomografia computadorizada. A imagem por ressonância magnética revelou lesäo isointensa em T1, com hiposinal em T2 e realce após a administraçäo de gadolíneo. Estes achados, juntamente com a evoluçäo clínica, auxiliam grandemente no diagnóstico diferencial da lesäo