1.
J Org Chem
; 86(9): 6160-6168, 2021 05 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33908786
RESUMO
A concise, (Z)-selective ring-closing metathesis (RCM) route to the 14-membered carbocycle of bielschowskysin is detailed using naturally occurring chiral starting materials. Unproductive RCM substrates were attributed to alkyne chelation of the ruthenium catalyst and steric disadvantages within the cembranoid precursors, which was eventually circumvented by using cyclic diol benzylidene protection involving a C8-quaternary carbinol center.