Detalhe da pesquisa
1.
Glucocorticoid receptors signaling impairment potentiates amyloid-ß oligomers-induced pathology in an acute model of Alzheimer's disease.
FASEB J
; 34(1): 1150-1168, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31914623
2.
Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases.
Int J Mol Sci
; 21(6)2020 Mar 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32244957
3.
Resetting the Stress System with a Mifepristone Challenge.
Cell Mol Neurobiol
; 39(4): 503-522, 2019 May.
Artigo
Inglês
| MEDLINE | ID: mdl-30173378
4.
Mifepristone Plasma Level and Glucocorticoid Receptor Antagonism Associated With Response in Patients With Psychotic Depression.
J Clin Psychopharmacol
; 37(5): 505-511, 2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28708736
5.
Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction.
Am J Physiol Endocrinol Metab
; 311(1): E56-68, 2016 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27143556
6.
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.
Proc Natl Acad Sci U S A
; 110(19): 7910-5, 2013 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23613579
7.
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.
Bioorg Med Chem Lett
; 25(24): 5720-5, 2015 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26546213
8.
Stress-induced Neuroinflammation of the Spinal Cord is Restrained by Cort113176 (Dazucorilant), A Specific Glucocorticoid Receptor Modulator.
Mol Neurobiol
; 61(1): 1-14, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37566177
9.
Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia.
J Neural Transm (Vienna)
; 119(3): 337-44, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21922193
10.
Biochemical and Radiological Changes in Liver Steatosis Following Mifepristone Treatment in Patients With Hypercortisolism.
AACE Clin Case Rep
; 8(1): 25-29, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35097198
11.
Efficacy and safety of mifepristone for the treatment of psychotic depression.
J Clin Psychopharmacol
; 31(4): 436-40, 2011 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-21694614
12.
Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration.
Brain Res
; 1727: 146551, 2020 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31726042
13.
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity.
Bioorg Med Chem Lett
; 18(4): 1312-7, 2008 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18226897
14.
Combined Analysis of Mifepristone for Psychotic Depression: Plasma Levels Associated With Clinical Response.
Biol Psychiatry
; 84(1): 46-54, 2018 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29523415
15.
Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double-Blind, Randomized, Placebo-Controlled Phase 1 Clinical Study.
Clin Pharmacol Drug Dev
; 7(4): 408-421, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28967708
16.
The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord.
Neuroscience
; 384: 384-396, 2018 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29890290
17.
Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice.
Endocrinology
; 159(12): 3925-3936, 2018 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30321321
18.
The use of mifepristone in the treatment of neuropsychiatric disorders.
Trends Endocrinol Metab
; 17(3): 117-21, 2006 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-16530421
19.
The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness.
J Steroid Biochem Mol Biol
; 165(Pt A): 114-120, 2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27002803
20.
Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.
J Med Chem
; 60(8): 3405-3421, 2017 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28368581