Detalhe da pesquisa
1.
Synthesis of Cystine-Stabilised Dicarba Conotoxin EpI: Ring-Closing Metathesis of Sidechain Deprotected, Sulfide-Rich Sequences.
Mar Drugs
; 21(7)2023 Jun 29.
Artigo
Inglês
| MEDLINE | ID: mdl-37504921
2.
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins.
Mar Drugs
; 21(2)2023 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-36827123
3.
Probing the correlation between insulin activity and structural stability through introduction of the rigid A6-A11 bond.
J Biol Chem
; 293(30): 11928-11943, 2018 07 27.
Artigo
Inglês
| MEDLINE | ID: mdl-29899115
4.
Negating coordinative cysteine and methionine residues during metathesis of unprotected peptides.
Chem Commun (Camb)
; 59(45): 6917-6920, 2023 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37200079
5.
Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone.
Biochem Biophys Res Commun
; 420(2): 253-6, 2012 Apr 06.
Artigo
Inglês
| MEDLINE | ID: mdl-22425984
6.
Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond.
Front Endocrinol (Lausanne)
; 13: 907864, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35832429
7.
Structure and function relationship of murine insulin-like peptide 5 (INSL5): free C-terminus is essential for RXFP4 receptor binding and activation.
Biochemistry
; 50(39): 8352-61, 2011 Oct 04.
Artigo
Inglês
| MEDLINE | ID: mdl-21866895
8.
Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models.
J Med Chem
; 64(6): 3222-3233, 2021 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33724033
9.
α-Conotoxin Peptidomimetics: Probing the Minimal Binding Motif for Effective Analgesia.
Toxins (Basel)
; 12(8)2020 08 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32781580
10.
Use of a temporary "solubilizing" peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation.
Bioconjug Chem
; 20(7): 1390-6, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19552405
11.
Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.
Sci Rep
; 7(1): 17239, 2017 12 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29222417
12.
Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue.
Toxicon
; 129: 113-122, 2017 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-28216409
13.
A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed ß-Hairpin Fold.
Structure
; 24(2): 293-9, 2016 Feb 02.
Artigo
Inglês
| MEDLINE | ID: mdl-26774129
14.
Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets.
J Med Chem
; 57(23): 9933-44, 2014 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25393758
15.
Minimum active structure of insulin-like peptide 5.
J Med Chem
; 56(23): 9509-16, 2013 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24188028
16.
Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors.
ACS Chem Biol
; 8(8): 1815-21, 2013 Aug 16.
Artigo
Inglês
| MEDLINE | ID: mdl-23768016
17.
Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.
J Med Chem
; 55(4): 1671-81, 2012 Feb 23.
Artigo
Inglês
| MEDLINE | ID: mdl-22257012