Detalhe da pesquisa
1.
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.
Mol Psychiatry
; 22(6): 820-835, 2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-27378147
2.
Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages.
PLoS Genet
; 8(3): e1002592, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22457638
3.
Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade.
Neurodegener Dis
; 7(1-3): 16-23, 2010.
Artigo
Inglês
| MEDLINE | ID: mdl-20160452
4.
Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits.
J Neurosci
; 28(18): 4690-701, 2008 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-18448646
5.
ApoE4-dependent Abeta-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum.
J Neural Transm (Vienna)
; 116(11): 1427-34, 2009 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19370389
6.
Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease.
Mol Neurobiol
; 56(6): 4464-4478, 2019 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-30334188
7.
Activation of the amyloid cascade by intracerebroventricular injection of the protease inhibitor phosphoramidon.
Neurodegener Dis
; 5(3-4): 166-9, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18322380
8.
Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.
JCI Insight
; 1(10)2016 Jul 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27525310
9.
Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.
Neuron
; 83(3): 558-71, 2014 Aug 06.
Artigo
Inglês
| MEDLINE | ID: mdl-25043421
10.
ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aß42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function.
Int J Alzheimers Dis
; 2011: 792070, 2011 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21350674
11.
Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-ß resulting in neurodegeneration.
J Alzheimers Dis
; 22(3): 959-70, 2010.
Artigo
Inglês
| MEDLINE | ID: mdl-20858958
12.
Pathological synergism between amyloid-beta and apolipoprotein E4--the most prevalent yet understudied genetic risk factor for Alzheimer's disease.
J Alzheimers Dis
; 17(3): 469-81, 2009.
Artigo
Inglês
| MEDLINE | ID: mdl-19363257
13.
Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.
J Neurochem
; 103(3): 1031-40, 2007 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17666042
14.
Neuron-specific susceptibility to apolipoprotein E4.
Neurobiol Aging
; 28(5): 689-92; discussion 704-6, 2007 May.
Artigo
Inglês
| MEDLINE | ID: mdl-17023093