Prognostic value of a history of hypertension in 11,483 patients with acute myocardial infarction treated with thrombolysis. GISSI-2 Investigators. Gruppo Italiano per lo Studio della, Sopravvivena nell'Infarto Miocardico.

OBJECTIVE: To assess the prognostic value of a history of hypertension in patients with acute myocardial infarction (AMI) treated with thrombolysis. DESIGN: Retrospective adjusted analysis of outcome data of patients with AMI randomly allocated to treatment in a controlled study of alteplase versus streptokinase and heparin versus no heparin. SETTING: A highly representative sample (about 90%) of Italian Coronary Care Units. PATIENTS: Patients with (n = 3306) and without (n = 7406) a history of treated hypertension. MAIN OUTCOME MEASURES: Morbidity and mortality during hospital stay and the next 6 months. RESULTS: Patients with a history of hypertension had a significantly higher mortality, both in hospital and during the next 6 months. The difference persisted also after a multivariate analysis including all major prognostic factors for in-hospital and 6-month mortality, respectively. Left ventricular failure and recurrent ischaemic events (angina and re-infarction) were also significantly more frequent in hypertensives both during their hospital stay and during follow-up study. CONCLUSIONS: A history of hypertension is a negative independent prognostic factor after acute myocardial infarction treated with thrombolysis.

Responses of internal mammary artery graft flow to nitroprusside: a duplex Doppler study in hypertensive hearts.

OBJECTIVE: To assess the response of internal mammary artery (IMA) flow of hypertensive hearts to nitroprusside infusion. METHODS: Fifteen patients were studied with a high-frequency duplex Doppler probe from the supraclavicolar approach. All the patients had undergone coronary artery bypass surgery with an IMA graft into the left anterior descending artery. The investigated patients were normotensives (controls, n = 5) and hypertensive with a normal (group 1, n = 5) or a hypertrophic (group 2, n = 5) left ventricle. Values of the left ventricular mass index were 102 +/- 11 g/m2 in controls, 115 +/- 18 g/m2 in group 1 and 153 +/- 8 g/m2 in group 2. The IMA flow volume was studied at baseline and continuously during nitroprusside infusion. The arterial blood pressure was measured each minute by a cuff sphygmomanometer. In each patient we considered the peak flow volume (percentage increment from baseline) and the flow volume at the end point (the lowest tolerated diastolic blood pressure). RESULTS: Nitroprusside infusion induced a comparable flow-volume increment in controls (38 +/- 27%) and in group 1 (24 +/- 11%). Conversely, the flow-volume increment was trivial in group 2 (6 +/- 6%). At the end point, the flow volume was similar to the baseline value in controls (with diastolic blood pressure 67 +/- 9 mmHg) and in group 1 (diastolic blood pressure 61 +/- 4 mmHg), whereas the flow volume declined significantly from baseline (by 23%) in group 2 at a perfusion pressure of 79 +/- 9 mmHg. CONCLUSION: Hypertensive patients with a normal left ventricular mass exhibit a coronary flow behaviour similar to that of normotensives in response to a nitroprusside infusion. Conversely, hypertrophic hypertensives show a blunted nitroprusside-induced coronary vasodilator response and are much more vulnerable to coronary flow reductions in the face of hypotension. This dynamic assessment of flow patterns can be obtained non-invasively by duplex Doppler monitoring of IMA graft flow.

[Use of topical methisoprinol (Viruxan) in female genital condylomatosis]. / Utilizzazione del metisoprinolo (Viruxan) per via topica nella condilomatosi genitale femminile.

Medical therapy of genital condylomatosis seems to be the most rational strategy, since this pathology is characterised by highly frequent recurrences after destructive physical therapy alone. Successful therapy of female genital condylomatosis with methisoprinol (Viruxan), administered as ointment and/or vaginal ovules is reported. The drug proved to be efficient both in curing this viral infection and preventing its recurrences.

[Acute viral myocarditis with transient concentric pseudohypertrophy of the left ventricle complicated by cardiogenic shock]. / Miocardite acuta virale con transitoria pseudoipertrofia concentrica del ventricolo sinistro complicata da shock cardiogeno.

The authors report the case of a 38-year-old woman with acute influenza myocarditis, cardiogenic shock and multiorgan injuries. The echocardiogram showed symmetric thickening and severe hypokinesis of the ventricular wall, with a concomitant reduction of the left ventricular cavity due to myocardial edema and cellular infiltration. The myocardial thickening gradually decreased and the ejection fraction improved, as shown by serial echocardiographic evaluations. Blood levels of cardiospecific enzymes were slightly elevated and ECG showed little change. The myocarditis resolved without sequelae. The hemodynamic implications of this transient myocardial thickening and its relationship to steroid therapy are discussed.

[Selective coronarography and left ventriculography using iopamidol in the early phase of myocardial infarct]. / Coronarografia selettiva e ventricolografia sinistra con iopamidolo nell'infarto miocardico in fase precoce.

The new techniques for an early treatment of acute myocardial infarction (AMI), such as thrombolysis and percutaneous transluminal angioplasty, often necessitate rapid and accurate radiological evaluation of coronaric lesions and left ventricular function. The aim of the present study was to evaluate both safety and tolerability of selective coronarography (SC) and left ventriculography (LVG), with iopamidol 370 mg I/ml as a contrast medium, in the acute phase of AMI. Thirty-nine patients aged 26-29 years, were examined: 18, group A, within 4 days (mean 2.6 +/- 0.8 SD) and 21, group B, within 5-15 days after AMI (mean 8.8 +/- 3 SD). Contrast media (cm) dosage varied from 150 to 300 ml (2.43-5.5 ml/bw). During the procedure, ECG was continuously recorded; left ventricular pressure was registered immediately before and 30 minutes after cm administration. During the following 9 days ECG tracings and plasmatic cytolysis enzymes were monitored. During the examinations no patient complained of any symptoms. After LVG slight elevations in end diastolic pressure were detected in all patients (mean increase 4.7 mmHg), which were not relevant from a clinical point of view. In 11/39 cases ventricular tachycardia was observed, which spontaneously ceased. During SC no change in ECG tracings was registered except in one patient, group A, in whom complete transitory heart block was detected. After SC no alteration in instrumental and biochemical parameters was registered except in one patient, group B, in whom a reinfarction due to right coronaric artery occlusion was observed. In conclusion, our results suggest that both SC and LVG with iopamidol are safe techniques also in the early phase of myocardial infarction.