Modeling the subjective perspective of consciousness and its role in the control of behaviours.

Consciousness has been hypothesized to operate as a global workspace, which accesses and integrates multimodal information in a unified manner, supports expectation violation monitoring and reduction, and the motivation, programming and control of action. One important yet open issue concerns how the subjective perspective at the core of consciousness, and subjective properties of manifestation of the environment in such perspective as an embodied experience, play a role in such process. We operationalised the concept of subjective perspective using the principles of the Projective Consciousness Model (PCM), based on the projective geometrical concept of Field of Consciousness. We show how these principles can account for documented relationships between appraisal and distance as an inverse distance law, yield a generative model of affective and epistemic drives based on purely subjective parameters, such as the apparent size of objects, and can be generalised to implement Theory of Mind, in a manner that is consistent with simulation theory. We used simulations of artificial agents, based on psychological rationale, to demonstrate how different model parameters could generate a variety of emergent adaptive and maladaptive behaviours that are relevant to developmental and clinical psychology: the ability to be resilient in the face of obstacles through imaginary projections, the emergence of social approach and joint attention behaviours, the ability to take advantage of false beliefs attributed to others, the emergence of avoidance behaviours as observed in social anxiety disorders, the presence of restricted interests as observed in autism spectrum disorders. The simulation of agents was applied to a specific robotic context, and agents' behaviours were demonstrated by controlling the corresponding robots. Our results contribute to advance the scientific understanding of the causal relationships between core aspects of the phenomenology of consciousness and its functions in human cybernetics.

Neopterin levels are independently associated with cardiac remodeling in patients with chronic heart failure.

OBJECTIVES: Neopterin, a marker of inflammation and monocyte activation, is found increased in patients with heart failure (HF). This study investigates whether neopterin levels correlate with left ventricular (LV) remodeling and brain natriuretic peptide (BNP), a marker of cardiac stress, in chronic HF (CHF) patients with different severity of disease. DESIGN AND METHODS: The relationship between neopterin and LV dimensions, NT-proBNP, and pro-inflammatory cytokines were studied in 98 CHF patients, while nineteen healthy subjects were enrolled as controls. Nineteen (19%) patients were in NYHA class I, 38 (39%) in NYHA class II, 27 (28%) in NYHA class III, and 14 (14%) in NYHA class IV. RESULTS: Neopterin levels were higher in CHF patients than in age- and gender-matched healthy controls, and related with indexed LV end-diastolic volume (LVEDVi). Prospectively CHF patients were separated into tertiles of low, medium and high neopterin levels. Among patients, male gender, LVEDVi, diuretic treatment, NYHA class I, NT-proBNP and IL-8 levels were significant determinants of urine neopterin levels by bivariate analysis. Neopterin levels were associated only to LV remodeling, as assessed by LVEDVi, and IL-8 levels, a crucial monocyte chemoattractant, by multivariate ordinal regression analysis. CONCLUSIONS: The relationship between elevated neopterin levels and LV enlargement in CHF patients suggests a crucial role of monocyte activation in the development of cardiac dysfunction in CHF patients. Assessment of neopterin levels is a potential biomarker to evaluate the progression of LV remodeling in CHF patients.