Pesquisa | Secretaria de Estado da Saúde

1.

Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength.

Elliot, Thomas A E; Jennings, Emma K; Lecky, David A J; Thawait, Natasha; Flores-Langarica, Adriana; Copland, Alastair; Maslowski, Kendle M; Wraith, David C; Bending, David.

Immunity ; 54(11): 2481-2496.e6, 2021 11 09.

Artigo Inglês | MEDLINE | ID: mdl-34534438

2.

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection.

Quintana, Juan F; Sinton, Matthew C; Chandrasegaran, Praveena; Kumar Dubey, Lalit; Ogunsola, John; Al Samman, Moumen; Haley, Michael; McConnell, Gail; Kuispond Swar, Nono-Raymond; Ngoyi, Dieudonné Mumba; Bending, David; de Lecea, Luis; MacLeod, Annette; Mabbott, Neil A.

PLoS Biol ; 21(11): e3002389, 2023 Nov.

Artigo Inglês | MEDLINE | ID: mdl-37983289

3.

FoxP3 partners up.

Bending, David; Ono, Masahiro.

Nat Immunol ; 18(11): 1181-1183, 2017 10 18.

Artigo Inglês | MEDLINE | ID: mdl-29044246

4.

A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme.

Bending, David; Paduraru, Alina; Ducker, Catherine B; Prieto Martín, Paz; Crompton, Tessa; Ono, Masahiro.

EMBO J ; 37(16)2018 08 15.

Artigo Inglês | MEDLINE | ID: mdl-29991564

5.

Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.

Bending, David; Giannakopoulou, Eirini; Lom, Hannah; Wedderburn, Lucy R.

J Immunol ; 195(12): 5616-24, 2015 Dec 15.

Artigo Inglês | MEDLINE | ID: mdl-26561546

6.

Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.

Bending, David; Pesenacker, Anne M; Ursu, Simona; Wu, Qiong; Lom, Hannah; Thirugnanabalan, Balathas; Wedderburn, Lucy R.

J Immunol ; 193(6): 2699-708, 2014 Sep 15.

Artigo Inglês | MEDLINE | ID: mdl-25092890

7.

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines.

Pesenacker, Anne M; Bending, David; Ursu, Simona; Wu, Qiong; Nistala, Kiran; Wedderburn, Lucy R.

Blood ; 121(14): 2647-58, 2013 Apr 04.

Artigo Inglês | MEDLINE | ID: mdl-23355538

8.

Inflammation and type one diabetes.

Bending, David; Zaccone, Paola; Cooke, Anne.

Int Immunol ; 24(6): 339-46, 2012 Jun.

Artigo Inglês | MEDLINE | ID: mdl-22447815

9.

Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells.

Bending, David; Newland, Stephen; Krejcí, Alena; Phillips, Jenny M; Bray, Sarah; Cooke, Anne.

J Immunol ; 186(6): 3373-82, 2011 Mar 15.

Artigo Inglês | MEDLINE | ID: mdl-21307296

10.

Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling.

Bending, David; Ono, Masahiro.

J Allergy Clin Immunol ; 139(6): 1790-1792, 2017 06.

Artigo Inglês | MEDLINE | ID: mdl-28392329

11.

Nr4a nuclear receptors: markers and modulators of antigen receptor signaling.

Bending, David; Zikherman, Julie.

Curr Opin Immunol ; 81: 102285, 2023 04.

Artigo Inglês | MEDLINE | ID: mdl-36764055

12.

T cell biomarkers come to the fore in cancer immunotherapy.

Sheriff, Lozan; Copland, Alastair; Bending, David.

Cell Rep Med ; 4(4): 100989, 2023 04 18.

Artigo Inglês | MEDLINE | ID: mdl-37001529

13.

T-cell response to checkpoint blockade immunotherapies: from fundamental mechanisms to treatment signatures.

Elliot, Thomas A E; Lecky, David A J; Bending, David.

Essays Biochem ; 67(6): 967-977, 2023 09 28.

Artigo Inglês | MEDLINE | ID: mdl-37386922

14.

Flow cytometric analysis of CD4+ T cell reactivation following anti-PD1 immunotherapy in a transgenic mouse model.

Sheriff, Lozan; Bending, David.

STAR Protoc ; 3(1): 101161, 2022 03 18.

Artigo Inglês | MEDLINE | ID: mdl-35169717

15.

Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation.

Gudgeon, Nancy; Munford, Haydn; Bishop, Emma L; Hill, James; Fulton-Ward, Taylor; Bending, David; Roberts, Jennie; Tennant, Daniel A; Dimeloe, Sarah.

Cell Rep ; 40(7): 111193, 2022 08 16.

Artigo Inglês | MEDLINE | ID: mdl-35977513

16.

Nur77-Tempo mice reveal T cell steady state antigen recognition.

Elliot, Thomas A E; Jennings, Emma K; Lecky, David A J; Rouvray, Sophie; Mackie, Gillian M; Scarfe, Lisa; Sheriff, Lozan; Ono, Masahiro; Maslowski, Kendle M; Bending, David.

Discov Immunol ; 1(1): kyac009, 2022 Dec 22.

Artigo Inglês | MEDLINE | ID: mdl-36704407

17.

Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria.

Drummond, Rebecca A; Desai, Jigar V; Ricotta, Emily E; Swamydas, Muthulekha; Deming, Clay; Conlan, Sean; Quinones, Mariam; Matei-Rascu, Veronika; Sherif, Lozan; Lecky, David; Lee, Chyi-Chia R; Green, Nathaniel M; Collins, Nicholas; Zelazny, Adrian M; Prevots, D Rebecca; Bending, David; Withers, David; Belkaid, Yasmine; Segre, Julia A; Lionakis, Michail S.

Cell Host Microbe ; 30(7): 1020-1033.e6, 2022 07 13.

Artigo Inglês | MEDLINE | ID: mdl-35568028

18.

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits.

Whyte, Carly E; Singh, Kailash; Burton, Oliver T; Aloulou, Meryem; Kouser, Lubna; Veiga, Rafael Valente; Dashwood, Amy; Okkenhaug, Hanneke; Benadda, Samira; Moudra, Alena; Bricard, Orian; Lienart, Stephanie; Bielefeld, Pascal; Roca, Carlos P; Naranjo-Galindo, Francisco José; Lombard-Vadnais, Félix; Junius, Steffie; Bending, David; Ono, Masahiro; Hochepied, Tino; Halim, Timotheus Y F; Schlenner, Susan; Lesage, Sylvie; Dooley, James; Liston, Adrian.

J Exp Med ; 219(7)2022 07 04.

Artigo Inglês | MEDLINE | ID: mdl-35699942

19.

Application of dual Nr4a1-GFP Nr4a3-Tocky reporter mice to study T cell receptor signaling by flow cytometry.

Jennings, Emma K; Lecky, David A J; Ono, Masahiro; Bending, David.

STAR Protoc ; 2(1): 100284, 2021 03 19.

Artigo Inglês | MEDLINE | ID: mdl-33532733

20.

Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration.

Jennings, Emma; Elliot, Thomas A E; Thawait, Natasha; Kanabar, Shivani; Yam-Puc, Juan Carlos; Ono, Masahiro; Toellner, Kai-Michael; Wraith, David C; Anderson, Graham; Bending, David.

Cell Rep ; 33(5): 108328, 2020 11 03.

Artigo Inglês | MEDLINE | ID: mdl-33147449

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