Detalhe da pesquisa
1.
Development of orally active inhibitors of protein and cellular fucosylation.
Proc Natl Acad Sci U S A
; 110(14): 5404-9, 2013 Apr 02.
Artigo
Inglês
| MEDLINE | ID: mdl-23493549
2.
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.
Blood
; 122(8): 1455-63, 2013 Aug 22.
Artigo
Inglês
| MEDLINE | ID: mdl-23770776
3.
Design, synthesis and selection of DNA-encoded small-molecule libraries.
Nat Chem Biol
; 5(9): 647-54, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19648931
4.
The pharmacologic basis for antibody-auristatin conjugate activity.
J Pharmacol Exp Ther
; 330(3): 932-8, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19498104
5.
Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody-Drug Conjugate Via Fc-FcγR Interaction.
Mol Cancer Ther
; 18(4): 780-787, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30824607
6.
Characterization of SGN-CD123A, A Potent CD123-Directed Antibody-Drug Conjugate for Acute Myeloid Leukemia.
Mol Cancer Ther
; 17(2): 554-564, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29142066
7.
Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody-Drug Conjugates.
Mol Cancer Ther
; 16(7): 1347-1354, 2017 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28341790
8.
Antibody-conjugated drug assay for protease-cleavable antibody-drug conjugates.
Bioanalysis
; 8(1): 55-63, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-26647801
9.
Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.
Cancer Res
; 76(9): 2710-9, 2016 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26921341
10.
The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-ĸB activation in transgenic sickle mice.
PLoS One
; 10(2): e0117772, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25706118
11.
SGN-LIV1A: a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer.
Mol Cancer Ther
; 13(12): 2991-3000, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25253783
12.
Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.
ACS Med Chem Lett
; 4(4): 381-6, 2013 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24900682
13.
Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate.
Clin Cancer Res
; 16(3): 888-97, 2010 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20086002
14.
Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
J Med Chem
; 52(24): 8047-56, 2009 Dec 24.
Artigo
Inglês
| MEDLINE | ID: mdl-19929003
15.
Contribution of linker stability to the activities of anticancer immunoconjugates.
Bioconjug Chem
; 19(3): 759-65, 2008 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-18314937