Detalhe da pesquisa
1.
Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species.
Drug Metab Dispos
; 47(10): 1111-1121, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31387871
2.
Species difference in glucuronidation formation kinetics with a selective mTOR inhibitor.
Drug Metab Dispos
; 42(4): 707-17, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24423753
3.
Dynamic modeling of cytochrome P450 inhibition in vitro: impact of inhibitor depletion on IC50 shift.
Drug Metab Dispos
; 41(7): 1433-41, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23649703
4.
Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors.
Drug Metab Dispos
; 41(1): 238-47, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23118327
5.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg Med Chem Lett
; 22(12): 4089-93, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22595176
6.
Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity.
BMC Pharmacol
; 12: 5, 2012 May 29.
Artigo
Inglês
| MEDLINE | ID: mdl-22642416
7.
Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.
Xenobiotica
; 42(9): 830-40, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22439758
8.
Species differences in distribution and prediction of human V(ss) from preclinical data.
Drug Metab Dispos
; 39(11): 2103-16, 2011 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-21852367
9.
In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases.
Xenobiotica
; 41(5): 400-8, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21294625
10.
Prediction of V(ss) from in vitro tissue-binding studies.
Drug Metab Dispos
; 38(1): 115-21, 2010 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19797608
11.
Relationship between passive permeability, efflux, and predictability of clearance from in vitro metabolic intrinsic clearance.
Drug Metab Dispos
; 38(2): 223-31, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19875499
12.
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Bioorg Med Chem Lett
; 19(22): 6307-12, 2009 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19819693
13.
N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy.
J Pharmacol Exp Ther
; 324(1): 188-95, 2008 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-17951511
14.
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
J Med Chem
; 51(10): 2879-82, 2008 May 22.
Artigo
Inglês
| MEDLINE | ID: mdl-18426196
15.
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
J Med Chem
; 51(6): 1668-80, 2008 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-18324759
16.
Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators.
Eur J Med Chem
; 137: 63-75, 2017 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28575722
17.
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.
J Med Chem
; 60(14): 5990-6017, 2017 07 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28324649
18.
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.
J Med Chem
; 59(17): 7818-39, 2016 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27441383
19.
Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats.
Biol Psychiatry
; 76(3): 213-22, 2014 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24090794
20.
Gender effects on rat metabolism of AMG 900, an orally available small molecule aurora kinase inhibitor.
Drug Metab Lett
; 5(4): 290-7, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-22022868