Detalhe da pesquisa
1.
Crystallographic snapshots of a B12-dependent radical SAM methyltransferase.
Nature
; 602(7896): 336-342, 2022 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35110733
2.
Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.
Nat Chem Biol
; 20(3): 382-391, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38158457
3.
Radical S-Adenosyl-l-Methionine Enzyme PylB: A C-Centered Radical to Convert l-Lysine into (3R)-3-Methyl-d-Ornithine.
J Am Chem Soc
; 146(10): 6493-6505, 2024 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-38426440
4.
Exploring the Biosynthetic Potential of TsrM, a B12 -dependent Radical SAM Methyltransferase Catalyzing Non-radical Reactions.
Chemistry
; 28(31): e202200627, 2022 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35253932
5.
Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes.
J Biol Chem
; 295(49): 16665-16677, 2020 12 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32972973
6.
Ruminococcin C, an anti-clostridial sactipeptide produced by a prominent member of the human microbiota Ruminococcus gnavus.
J Biol Chem
; 294(40): 14512-14525, 2019 10 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31337708
7.
A missed Fe-S cluster handoff causes a metabolic shakeup.
J Biol Chem
; 293(21): 8312-8313, 2018 05 25.
Artigo
Inglês
| MEDLINE | ID: mdl-29802141
8.
Insights into the catalysis of a lysine-tryptophan bond in bacterial peptides by a SPASM domain radical S-adenosylmethionine (SAM) peptide cyclase.
J Biol Chem
; 292(26): 10835-10844, 2017 06 30.
Artigo
Inglês
| MEDLINE | ID: mdl-28476884
9.
Mechanistic Investigations of PoyD, a Radical S-Adenosyl-l-methionine Enzyme Catalyzing Iterative and Directional Epimerizations in Polytheonamide A Biosynthesis.
J Am Chem Soc
; 140(7): 2469-2477, 2018 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-29253341
10.
The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cß-Methylation during Polytheonamide Biosynthesis.
J Am Chem Soc
; 138(48): 15515-15518, 2016 12 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27934015
11.
Sulfatases and radical SAM enzymes: emerging themes in glycosaminoglycan metabolism and the human microbiota.
Biochem Soc Trans
; 44(1): 109-15, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26862195
12.
Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase.
J Biol Chem
; 289(35): 24289-303, 2014 Aug 29.
Artigo
Inglês
| MEDLINE | ID: mdl-25002587
13.
Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis.
J Am Chem Soc
; 137(16): 5406-13, 2015 Apr 29.
Artigo
Inglês
| MEDLINE | ID: mdl-25781338
14.
Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes.
Nat Chem Biol
; 8(12): 957-9, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23064318
15.
A metagenomic ß-glucuronidase uncovers a core adaptive function of the human intestinal microbiome.
Proc Natl Acad Sci U S A
; 108 Suppl 1: 4539-46, 2011 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20615998
16.
An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily.
Proc Natl Acad Sci U S A
; 107(7): 2740-5, 2010 Feb 16.
Artigo
Inglês
| MEDLINE | ID: mdl-20133613
17.
B12-dependent radical SAM enzymes: Ever expanding structural and mechanistic diversity.
Curr Opin Struct Biol
; 83: 102725, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37931378
18.
Sulfatases and a radical S-adenosyl-L-methionine (AdoMet) enzyme are key for mucosal foraging and fitness of the prominent human gut symbiont, Bacteroides thetaiotaomicron.
J Biol Chem
; 286(29): 25973-82, 2011 Jul 22.
Artigo
Inglês
| MEDLINE | ID: mdl-21507958
19.
Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate.
J Am Chem Soc
; 134(44): 18173-6, 2012 Nov 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23072415
20.
Radical SAM Enzymes and Ribosomally-Synthesized and Post-translationally Modified Peptides: A Growing Importance in the Microbiomes.
Front Chem
; 9: 678068, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34350157