Detalhe da pesquisa
1.
Nicotinic acetylcholine receptors in neurological and psychiatric diseases.
Pharmacol Res
; 191: 106764, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37044234
2.
The SARS-CoV-2 Virus and the Cholinergic System: Spike Protein Interaction with Human Nicotinic Acetylcholine Receptors and the Nicotinic Agonist Varenicline.
Int J Mol Sci
; 24(6)2023 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36982671
3.
Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site.
J Biol Chem
; 297(2): 100899, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34157288
4.
A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat Chem Biol
; 15(12): 1156-1164, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31591563
5.
Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 112(19): E2543-52, 2015 May 12.
Artigo
Inglês
| MEDLINE | ID: mdl-25918415
6.
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors.
Pharmacol Rev
; 67(4): 1025-73, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26419447
7.
The solithromycin journey-It is all in the chemistry.
Bioorg Med Chem
; 24(24): 6420-6428, 2016 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27595539
8.
An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejana.
J Biol Chem
; 289(21): 15130-40, 2014 May 23.
Artigo
Inglês
| MEDLINE | ID: mdl-24719323
9.
R-(+) and S-(-) isomers of cotinine augment cholinergic responses in vitro and in vivo.
J Pharmacol Exp Ther
; 352(2): 405-18, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25503389
10.
The nicotinic acetylcholine receptor alpha 4 subunit contains a functionally relevant SNP Haplotype.
BMC Genet
; 16: 46, 2015 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-25934188
11.
Functional characterization of AT-1001, an α3ß4 nicotinic acetylcholine receptor ligand, at human α3ß4 and α4ß2 nAChR.
Nicotine Tob Res
; 17(3): 361-7, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25180076
12.
Molecular actions of smoking cessation drugs at α4ß2 nicotinic receptors defined in crystal structures of a homologous binding protein.
Proc Natl Acad Sci U S A
; 109(23): 9173-8, 2012 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-22619328
13.
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.
Proc Natl Acad Sci U S A
; 109(44): E3028-34, 2012 Oct 30.
Artigo
Inglês
| MEDLINE | ID: mdl-23035248
14.
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).
J Biol Chem
; 288(12): 8355-8364, 2013 Mar 22.
Artigo
Inglês
| MEDLINE | ID: mdl-23364792
15.
Characterization of RO5126946, a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator.
J Pharmacol Exp Ther
; 350(2): 455-68, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24917542
16.
Functional interactions of varenicline and nicotine with nAChR subtypes implicated in cardiovascular control.
Nicotine Tob Res
; 16(6): 733-42, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24406270
17.
Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery.
Expert Opin Drug Discov
; 19(2): 173-187, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-37850233
18.
Dimeric α-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors.
J Biol Chem
; 287(9): 6725-34, 2012 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-22223648
19.
Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor.
J Biol Chem
; 287(32): 27079-86, 2012 Aug 03.
Artigo
Inglês
| MEDLINE | ID: mdl-22613724
20.
α7ß2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfaces.
Mol Pharmacol
; 81(2): 175-88, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-22039094