Detalhe da pesquisa
1.
Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides.
Bioconjug Chem
; 33(8): 1441-1445, 2022 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-35894801
2.
Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2.
J Med Chem
; 66(14): 9881-9893, 2023 07 27.
Artigo
Inglês
| MEDLINE | ID: mdl-37433017
3.
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Nat Commun
; 14(1): 3583, 2023 06 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37328472
4.
Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics.
Antibiotics (Basel)
; 11(11)2022 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36421280
5.
Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer.
J Med Chem
; 65(21): 14337-14347, 2022 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36204777
6.
BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors.
Mol Cancer Ther
; 21(12): 1747-1756, 2022 12 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36112771
7.
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
Bioorg Med Chem Lett
; 21(10): 3037-40, 2011 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21482467
8.
Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.
Bioorg Med Chem Lett
; 20(16): 4951-4, 2010 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20634071
9.
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.
Bioorg Med Chem Lett
; 20(10): 3161-4, 2010 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20399651
10.
Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.
Bioorg Med Chem Lett
; 20(15): 4653-6, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20579878
11.
Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.
Bioorg Med Chem Lett
; 20(2): 465-8, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20005703
12.
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.
Bioorg Med Chem Lett
; 20(22): 6370-4, 2010 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20934331
13.
Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.
Bioorg Med Chem Lett
; 20(17): 5080-4, 2010 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20673717
14.
An Assay for Periplasm Entry Advances the Development of Chimeric Peptide Antibiotics.
ACS Infect Dis
; 6(9): 2355-2361, 2020 09 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32697574
15.
2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.
Bioorg Med Chem Lett
; 19(23): 6578-81, 2009 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19864133
16.
Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
Bioorg Med Chem Lett
; 19(15): 4509-14, 2009 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19523822
17.
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.
Bioorg Med Chem Lett
; 19(15): 4504-8, 2009 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19520573
18.
A challenge finding P2X1 and P2X4 ligands.
Neuropharmacology
; 157: 107674, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31238045
19.
BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Bioorg Med Chem Lett
; 18(3): 1022-6, 2008 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18171615
20.
African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase.
Eur J Med Chem
; 141: 676-689, 2017 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29107420