Detalhe da pesquisa
1.
Spider phylosymbiosis: divergence of widow spider species and their tissues' microbiomes.
BMC Evol Biol
; 20(1): 104, 2020 08 18.
Artigo
Inglês
| MEDLINE | ID: mdl-32811423
2.
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
N Engl J Med
; 376(1): 41-51, 2017 01 05.
Artigo
Inglês
| MEDLINE | ID: mdl-27959715
3.
Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.
Mol Ther
; 25(1): 71-78, 2017 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28129130
4.
An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.
J Am Soc Nephrol
; 28(2): 494-503, 2017 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27432743
5.
Safety and efficacy of RNAi therapy for transthyretin amyloidosis.
N Engl J Med
; 369(9): 819-29, 2013 Aug 29.
Artigo
Inglês
| MEDLINE | ID: mdl-23984729
6.
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.
Lancet
; 383(9911): 60-68, 2014 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-24094767
7.
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine ß-thalassemia intermedia.
Blood
; 121(7): 1200-8, 2013 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-23223430
8.
Organization and evolution of hsp70 clusters strikingly differ in two species of Stratiomyidae (Diptera) inhabiting thermally contrasting environments.
BMC Evol Biol
; 11: 74, 2011 Mar 22.
Artigo
Inglês
| MEDLINE | ID: mdl-21426536
9.
Duplicate gene evolution toward multiple fates at the Drosophila melanogaster HIP/HIP-Replacement locus.
J Mol Evol
; 68(4): 337-50, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19333534
10.
Natural variation in Drosophila stressed locomotion meets or exceeds variation caused by hsp70 mutation: analysis of behavior and performance.
Behav Genet
; 39(3): 306-20, 2009 May.
Artigo
Inglês
| MEDLINE | ID: mdl-19242787
11.
Inducible and constitutive heat shock gene expression responds to modification of Hsp70 copy number in Drosophila melanogaster but does not compensate for loss of thermotolerance in Hsp70 null flies.
BMC Biol
; 6: 5, 2008 Jan 22.
Artigo
Inglês
| MEDLINE | ID: mdl-18211703
12.
Polyglutamine expansion in Drosophila: thermal stress and Hsp70 as selective agents.
J Biosci
; 32(3): 537-47, 2007 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-17536173
13.
ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients.
J Heart Lung Transplant
; 35(2): 213-21, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26452996
14.
Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.
Amyloid
; 23(2): 109-18, 2016 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-27033334
15.
Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study.
Orphanet J Rare Dis
; 10: 109, 2015 Sep 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26338094
16.
Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study.
Neurology
; 85(8): 675-82, 2015 Aug 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26208957
17.
Response to natural and laboratory selection at the Drosophila hsp70 genes.
Evolution
; 56(9): 1796-801, 2002 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-12389724
18.
In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR).
Silence
; 1(1): 16, 2010 Aug 23.
Artigo
Inglês
| MEDLINE | ID: mdl-20731861
19.
Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects.
PLoS One
; 5(12): e15264, 2010 Dec 17.
Artigo
Inglês
| MEDLINE | ID: mdl-21253006
20.
Evolution of proteins and gene expression levels are coupled in Drosophila and are independently associated with mRNA abundance, protein length, and number of protein-protein interactions.
Mol Biol Evol
; 22(5): 1345-54, 2005 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15746013