Conceptual foundations of physiological regulation incorporating the free energy principle and self-organized criticality.

Bettinger, J. S., K. J. Friston. Conceptual Foundations of Physiological Regulation incorporating the Free Energy Principle & Self-Organized Criticality. NEUROSCI BIOBEHAV REV 23(x) 144-XXX, 2022. Since the late nineteen-nineties, the concept of homeostasis has been contextualized within a broader class of "allostatic" dynamics characterized by a wider-berth of causal factors including social, psychological and environmental entailments; the fundamental nature of integrated brain-body dynamics; plus the role of anticipatory, top-down constraints supplied by intrinsic regulatory models. Many of these evidentiary factors are integral in original descriptions of homeostasis; subsequently integrated; and/or cite more-general operating principles of self-organization. As a result, the concept of allostasis may be generalized to a larger category of variational systems in biology, engineering and physics in terms of advances in complex systems, statistical mechanics and dynamics involving heterogenous (hierarchical/heterarchical, modular) systems like brain-networks and the internal milieu. This paper offers a three-part treatment. 1) interpret "allostasis" to emphasize a variational and relational foundation of physiological stability; 2) adapt the role of allostasis as "stability through change" to include a "return to stability" and 3) reframe the model of homeostasis with a conceptual model of criticality that licenses the upgrade to variational dynamics.

Foundations of anticipatory logic in biology and physics.

Recent advances in modern physics and biology reveal several scenarios in which top-down effects (Ellis, 2016) and anticipatory systems (Rosen, 1980) indicate processes at work enabling active modeling and inference such that anticipated effects project onto potential causes. We extrapolate a broad landscape of anticipatory systems in the natural sciences extending to computational neuroscience of perception in the capacity of Bayesian inferential models of predictive processing. This line of reasoning also comes with philosophical foundations, which we develop in terms of counterfactual reasoning and possibility space, Whitehead's process thought, and correlations with Eastern wisdom traditions.