Cu(I)-Induced Activation of Furan for Inverse Electron Demand ADAR with Alkenes toward Regioselective Synthesis of Tetrahydropyridine.

The aza-Diels-Alder reaction of various alkenes and in situ formed 1-aza-1,3-dienes from the reaction of furan/pyrrole/thiophene and PhINTs for the regioselective synthesis of tetrahydropyridine (THP) derivatives was realized. The reaction was catalyzed by TpMe2Cu as a catalyst under very mild reaction conditions. Structurally different alkenes, along with an alkyne, have been utilized as dienophiles to afford a wide range of different THP derivatives up to 70% yield. The potential application of the envisaged method was also investigated by a gram-scale synthesis.

Metal-free C-H Activation over Graphene Oxide toward Direct Syntheses of Structurally Different Amines and Amides in Water.

Unprecedented metal-free synthesis of a variety of amines and amides is reported via amination of C(sp3)-H and C(sp2)-H bonds. The strategy involves graphene-oxide/I2-catalyzed nitrene insertion using PhINTs as a nitrene (NT) source in water at room temperature. A wide range of structurally different substrates, viz., cyclohexane, cyclic ethers, arenes, alkyl aromatic systems, and aldehydes/ketones, having an α-phenyl ring have been employed successfully to afford the corresponding nitrene insertion product in good yield, albeit low in few cases. The envisaged method has superiority over others in terms of its operational simplicity, metal-free catalysis, use of water as a solvent, ambient reaction conditions, and reusability of the catalyst.

Electrocatalytic quantification of quinol in cosmetic samples using Co-doped graphitic carbon nitride @biomolecule assisted electrochemically reduced graphene nanosheets.

A bio-nanocomposite "Co-doped-g-C3N4@ biomolecule assisted electrochemically reduced graphene nanosheets (Co-g-C3N4@GNbme)" was prepared by electrochemical exfoliation of GO from graphite anode in the presence of amino acid 'l-cysteine' followed by its association with Co-g-C3N4. The preparation of material has been confirmed by characterizations with FTIR, XRD, XPS and Raman spectroscopy. The morphology was investigated with TEM and SEM. Further, Co-g-C3N4@GNbme modified GC electrode was utilized for detecting and quantifying the 'Quinol' (a skin lightning agent) in cosmetic samples electrochemically. Quinol is a fundamental constituent utilized in various industries such as pharmaceuticals, oil refineries, textiles, and dyes. In the realm of cosmetics, it is utilized as a skin-lightning agent to inhibit the production of melanin in the skin. However, prolonged use of this component often results in allergic reactions among individuals. Furthermore, the effluents discharged from its manufacturing units pose a significant threat to the environment and human health due to its slow degradation. The detection limit was calculated to be 2.4 nM (S/N = 3).