Detalhe da pesquisa
1.
Synthetic group A streptogramin antibiotics that overcome Vat resistance.
Nature
; 586(7827): 145-150, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32968273
2.
Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles.
Proc Natl Acad Sci U S A
; 117(52): 33204-33215, 2020 12 29.
Artigo
Inglês
| MEDLINE | ID: mdl-33376217
3.
Keep on moving: discovering and perturbing the conformational dynamics of enzymes.
Acc Chem Res
; 48(2): 423-30, 2015 Feb 17.
Artigo
Inglês
| MEDLINE | ID: mdl-25539415
4.
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B.
Elife
; 122023 03 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36881464
5.
Ensemble-function relationships to dissect mechanisms of enzyme catalysis.
Sci Adv
; 8(41): eabn7738, 2022 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36240280
6.
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
Sci Adv
; 7(16)2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33853786
7.
Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
bioRxiv
; 2020 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-33269349
8.
Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.
IUCrJ
; 7(Pt 2): 306-323, 2020 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32148858
9.
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Elife
; 72018 06 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29877794
10.
Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.
Structure
; 25(5): 739-749.e3, 2017 05 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28416112