Detalhe da pesquisa
1.
AKR1C3 mediates pan-AR antagonist resistance in castration-resistant prostate cancer.
Prostate
; 80(14): 1223-1232, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33258507
2.
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.
Bioorg Med Chem Lett
; 28(12): 2159-2164, 2018 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29779975
3.
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.
Bioorg Med Chem Lett
; 25(3): 602-6, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25556095
4.
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer.
ACS Med Chem Lett
; 12(8): 1245-1252, 2021 Aug 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34422225
5.
Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer.
Mol Cancer Ther
; 20(5): 763-774, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33649102
6.
Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).
J Med Chem
; 64(2): 909-924, 2021 01 28.
Artigo
Inglês
| MEDLINE | ID: mdl-33470111
7.
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.
Cell Chem Biol
; 28(2): 134-147.e14, 2021 02 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33086052
8.
Synthesis of an Epimer of a 16-Membered Ring Model for Teicoplanin: Confirmation of Epimerization during Cycloamidation.
J Org Chem
; 62(13): 4536-4538, 1997 Jun 27.
Artigo
Inglês
| MEDLINE | ID: mdl-11671792
9.
Cycloetherification Reactions of Areneruthenium Complexes: Construction of a 16-Membered Cyclic Peptide Model for Teicoplanin.
J Org Chem
; 61(12): 3940-3941, 1996 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-11667263
10.
3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor.
Bioorg Med Chem Lett
; 16(13): 3524-8, 2006 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16632355
11.
Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor.
Bioorg Med Chem Lett
; 15(22): 5022-6, 2005 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16153834
12.
A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models.
Mol Pharmacol
; 66(3): 635-47, 2004 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-15322256