Detalhe da pesquisa
1.
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.
Nature
; 559(7712): 125-129, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29950729
2.
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Nature
; 556(7702): 501-504, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29670287
3.
Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies.
Drug Metab Dispos
; 49(10): 870-881, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34321251
4.
AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Blood
; 130(11): 1347-1356, 2017 09 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28760888
5.
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.
Proc Natl Acad Sci U S A
; 112(29): 9088-93, 2015 Jul 21.
Artigo
Inglês
| MEDLINE | ID: mdl-26150517
6.
IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.
Blood
; 125(2): 296-303, 2015 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-25398940
7.
A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.
J Inherit Metab Dis
; 39(6): 807-820, 2016 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27469509
8.
FOCUS--Development of a Global Communication and Modeling Platform for Applied and Computational Medicinal Chemists.
J Chem Inf Model
; 55(4): 896-908, 2015 Apr 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25816021
9.
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads.
J Med Chem
; 65(6): 4600-4615, 2022 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-35293760
10.
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J Med Chem
; 64(8): 4430-4449, 2021 04 22.
Artigo
Inglês
| MEDLINE | ID: mdl-33829783
11.
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.
Cancer Cell
; 39(2): 209-224.e11, 2021 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33450196
12.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
Mol Cancer Ther
; 19(12): 2502-2515, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-33082276
13.
Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.
ACS Med Chem Lett
; 11(2): 101-107, 2020 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32071674
14.
Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML.
Blood Adv
; 4(9): 1894-1905, 2020 05 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32380538
15.
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
Nat Commun
; 10(1): 97, 2019 01 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30626872
16.
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Nat Commun
; 10(1): 96, 2019 01 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30626880
17.
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 51(5): 1145-9, 2008 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-18260618
18.
Tetrazole based amides as growth hormone secretagogues.
Bioorg Med Chem Lett
; 18(8): 2536-9, 2008 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18378446
19.
Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.
Bioorg Med Chem Lett
; 18(6): 2067-72, 2008 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18282707
20.
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers.
ACS Med Chem Lett
; 9(4): 300-305, 2018 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29670690