Detalhe da pesquisa
1.
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg Med Chem Lett
; 27(18): 4370-4376, 2017 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28830649
2.
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.
Proc Natl Acad Sci U S A
; 111(22): 8025-30, 2014 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-24843152
3.
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.
Cell Death Differ
; 27(1): 161-175, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31101885
4.
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
J Med Chem
; 56(11): 4764-85, 2013 Jun 13.
Artigo
Inglês
| MEDLINE | ID: mdl-23659214
5.
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
J Med Chem
; 55(12): 5901-21, 2012 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-22591402
6.
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
J Med Chem
; 55(13): 6176-93, 2012 Jul 12.
Artigo
Inglês
| MEDLINE | ID: mdl-22698084