RESUMO
Twenty-five patients with mass lesions involving the musculoskeletal system were studied with positron emission tomography (PET) in order to determine if a relationship exists between histologic grade and tumor uptake of [fluorine-18]2-deoxy-2-fluoro-D-glucose (FDG). There were 6 benign lesions and 19 malignant lesions of various grades. A high correlation (Rho = 0.83) was found between the normalized uptake of tracer and the NCl grade. The high-grade malignancies had significantly greater (p = 0.0091) uptake of FDG than the combination of benign lesions and low-grade malignancies. All lesions with a normalized uptake value of 1.6 or greater were high-grade, while all lesions less than 1.6 represented either benign tumors or low grade malignancies. This strong relationship between FDG uptake and grade among neoplasms from a wide variety of cell types within a single organ system suggests that the technique may be useful in predicting grade even when the cell type is unknown.
Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Doenças Musculares/diagnóstico por imagem , Neoplasias de Tecidos Moles/diagnóstico por imagem , Tomografia Computadorizada de Emissão , Desoxiglucose/análogos & derivados , Feminino , Radioisótopos de Flúor , Fluordesoxiglucose F18 , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Fibroma/diagnóstico , Histiocitoma Fibroso Benigno/diagnóstico , Perna (Membro) , Imageamento por Ressonância Magnética/normas , Cintilografia/normas , Neoplasias de Tecidos Moles/diagnóstico , Tomografia Computadorizada de Emissão/normas , Tomografia Computadorizada por Raios X/normas , Idoso , Idoso de 80 Anos ou mais , Estudos de Avaliação como Assunto , Feminino , Fibroma/diagnóstico por imagem , Histiocitoma Fibroso Benigno/diagnóstico por imagem , Humanos , Masculino , Neoplasias de Tecidos Moles/diagnóstico por imagem , Tomografia Computadorizada de Emissão/métodosRESUMO
Five patients with liposarcomas of the thigh were studied using positron emission tomography (PET) with [18F]2-deoxy-2-fluoroglucose (FDG). There were three low-grade tumors (all National Cancer Institute Grade 1 myxoid liposarcomas) and two high-grade tumors (both pleomorphic liposarcomas, Grades 2 and 3). The low-grade liposarcomas were easily identified with an average dose uptake ratio (DUR) of 1.38 +/- 0.045 (mean +/- SD). The high-grade lesions were more avid for FDG with a mean DUR of 2.45 +/- 0.24. There was a significant difference (p = 0.004) in the DUR for the two groups and the histological grade of malignancy was highly correlated with the DUR for FDG (Rho = 0.89). These findings suggest that FDG-PET may be useful for distinguishing between low-grade and high-grade liposarcomas.