Detalhe da pesquisa
1.
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Nature
; 546(7658): 376-380, 2017 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28562588
2.
Targeting Plasmodium PI(4)K to eliminate malaria.
Nature
; 504(7479): 248-253, 2013 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24284631
3.
PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites.
Antimicrob Agents Chemother
; 60(5): 2858-63, 2016 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26926645
4.
Small molecule inhibitors that selectively block dengue virus methyltransferase.
J Biol Chem
; 286(8): 6233-40, 2011 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-21147775
5.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
J Med Chem
; 65(5): 3798-3813, 2022 03 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35229610
6.
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.
Anal Biochem
; 395(2): 195-204, 2009 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19682971
7.
Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages.
Nat Commun
; 10(1): 3635, 2019 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31406175
8.
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.
Sci Transl Med
; 9(387)2017 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28446690
9.
Interpretation of protein folding psi values.
J Mol Biol
; 351(2): 393-401, 2005 Aug 12.
Artigo
Inglês
| MEDLINE | ID: mdl-16005895
10.
Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages.
ACS Med Chem Lett
; 5(8): 947-50, 2014 Aug 14.
Artigo
Inglês
| MEDLINE | ID: mdl-25147620
11.
Detection and quantification of flavivirus NS5 methyl-transferase activities.
Methods Mol Biol
; 1030: 249-68, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23821274
12.
Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.
Cell Host Microbe
; 11(6): 654-63, 2012 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-22704625
13.
Drug discovery for the developing world: progress at the Novartis Institute for Tropical Diseases.
Nat Rev Drug Discov
; 14(6): 442-4, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-26027536
14.
Crystal structure of the dengue virus methyltransferase bound to a 5'-capped octameric RNA.
PLoS One
; 5(9)2010 Sep 17.
Artigo
Inglês
| MEDLINE | ID: mdl-20862256
15.
Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics.
J Med Chem
; 52(15): 4860-8, 2009 Aug 13.
Artigo
Inglês
| MEDLINE | ID: mdl-19572550
16.
Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.
PLoS Negl Trop Dis
; 3(1): e356, 2009.
Artigo
Inglês
| MEDLINE | ID: mdl-19159012
17.
Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin.
J Biol Chem
; 281(25): 16914-16926, 2006 Jun 23.
Artigo
Inglês
| MEDLINE | ID: mdl-16627468
18.
Kinetic analysis of R67 dihydrofolate reductase folding: from the unfolded monomer to the native tetramer.
Biochemistry
; 41(50): 14988-99, 2002 Dec 17.
Artigo
Inglês
| MEDLINE | ID: mdl-12475248
19.
Antifolding activity of the SecB chaperone is essential for secretion of HasA, a quickly folding ABC pathway substrate.
J Biol Chem
; 278(40): 38247-53, 2003 Oct 03.
Artigo
Inglês
| MEDLINE | ID: mdl-12829711