RESUMO
The "adenosine" and "non-adenosine" mechanisms of adenine nucleotide (ATP, ADP, AMP KP) metabolism were studied in 58 patients with myocardial infarction. Predominant activation of the "adenosine" mechanism of metabolism was revealed in patients with acute myocardial infarction with a marked pain syndrome in the first 24 hours of the disease. In the painless form of myocardial infarction the "nonadenosine" nucleotide metabolism is activated while the "adenosine" type is inhibited. The determination and comparison of indices reflecting the condition of the "adenosine" and "nonadenosine" mechanisms of metabolism provide the possibility for evaluating the severity of the pathological process and, on this basis, elaborating a differentiated approach to the treatment of the patient.
Assuntos
Nucleotídeos de Adenina/sangue , Infarto do Miocárdio/sangue , Adulto , Idoso , Angina Pectoris/sangue , Ativação Enzimática , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de TempoRESUMO
Electrocardiography and tetrapolar rheoplethysmography of the finger have demonstrated that voltaren and 5-NK activity produce an adverse action on the coronary blood flow in patients with rheumatoid arthritis. It has been found possible to correct the induced disorders by cordarone.
Assuntos
Artrite Reumatoide/tratamento farmacológico , Circulação Coronária/efeitos dos fármacos , Diclofenaco/efeitos adversos , Adulto , Artrite Reumatoide/fisiopatologia , Diclofenaco/uso terapêutico , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pletismografia de ImpedânciaAssuntos
Angina Pectoris/tratamento farmacológico , Nitroglicerina/uso terapêutico , Administração Cutânea , Adulto , Idoso , Angina Pectoris/fisiopatologia , Angina Instável/tratamento farmacológico , Ensaios Clínicos como Assunto , Preparações de Ação Retardada , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Nitroglicerina/administração & dosagem , Nitroglicerina/farmacologiaRESUMO
A study is presented in 59 patients with dilated cardiomyopathy and 41 patients with ischemic heart disease. Diverse changes of the indices of lipid metabolism antioxidant system and metabolism of adenylic nucleotides, data of transesophageal stimulation of the left atrium indicate that these values along with clinical findings are of importance for the differential diagnosis of dilated cardiomyopathy and atherosclerotic myocardial sclerosis.