Detalhe da pesquisa
1.
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
J Pharmacol Exp Ther
; 372(3): 339-353, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31818916
2.
Development of a high-content imaging assay for screening compound aggregation.
Anal Biochem
; 559: 30-33, 2018 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30142329
3.
Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
Mol Pharmacol
; 88(6): 1011-23, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26438213
4.
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
J Med Chem
; 64(21): 15949-15972, 2021 11 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34705450
5.
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
J Med Chem
; 64(15): 11570-11596, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34279934
6.
Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors.
ACS Med Chem Lett
; 11(2): 133-140, 2020 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32071679
7.
Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery.
Sci Rep
; 9(1): 13078, 2019 09 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31511536
8.
A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1.
SLAS Discov
; 23(1): 34-46, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28957646
9.
Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.
Structure
; 24(5): 774-781, 2016 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27066749
10.
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.
Cancer Cell
; 28(1): 57-69, 2015 Jul 13.
Artigo
Inglês
| MEDLINE | ID: mdl-26175415