RESUMO
Post-vaccination granulomas a well-known reaction due to aluminium adsorbed vaccines. We report three cases of children who developed subcutaneous nodules at the site of a previous injection of Tetracoq*vaccine (tetanus, diphtheria, Bordetella pertussis, poliovirus). Histologically, the lesions were characterized by a necrotizing granulomatous reaction with eosinophilic crystalline material. This material stained positively with the solochrome cyanine stain and was pink-purple. This aluminium stain enabled diagnosis of post-immunization injection-site reaction due to aluminium.
Assuntos
Hidróxido de Alumínio/efeitos adversos , Granuloma/induzido quimicamente , Vacinas/efeitos adversos , Hidróxido de Alumínio/análise , Pré-Escolar , Corantes , Cristalização , Vacina contra Difteria, Tétano e Coqueluche/efeitos adversos , Feminino , Granuloma/patologia , Humanos , Lactente , Masculino , Necrose , Vacinas contra Poliovirus/efeitos adversosRESUMO
INTRODUCTION: Mycobacterium chelonae is an ubiquitous mycobacterium which is exceptionally pathogenic. It can cause localized skin infections which are difficult to treat because of multiple drug-resistance. CASE REPORT: A 87-year-old woman with bullous pemphigoid was treated with long-term prednisone and developed a skin infection due to M. Chelonae. Treatment with clarithromycin was successful, but relapse occurred 6 months after withdrawal of the antibiotic. DISCUSSION: Clarithromycin is effective in single drug regimen for M. Chelonae infection, but the duration of treatment should be long when immunosuppression cannot be avoided.