Pesquisa | Secretaria de Estado da Saúde

1.

N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.

Jansen, Robert S; Addie, Ruben; Merkx, Remco; Fish, Alexander; Mahakena, Sunny; Bleijerveld, Onno B; Altelaar, Maarten; IJlst, Lodewijk; Wanders, Ronald J; Borst, P; van de Wetering, Koen.

Proc Natl Acad Sci U S A ; 112(21): 6601-6, 2015 May 26.

Artigo Inglês | MEDLINE | ID: mdl-25964343

2.

ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release.

Jansen, Robert S; Küçükosmanoglu, Asli; de Haas, Marcel; Sapthu, Sunny; Otero, Jon Andoni; Hegman, Ilse E M; Bergen, Arthur A B; Gorgels, Theo G M F; Borst, P; van de Wetering, Koen.

Proc Natl Acad Sci U S A ; 110(50): 20206-11, 2013 Dec 10.

Artigo Inglês | MEDLINE | ID: mdl-24277820

3.

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

Wijnholds, J; Evers, R; van Leusden, M R; Mol, C A; Zaman, G J; Mayer, U; Beijnen, J H; van der Valk, M; Krimpenfort, P; Borst, P.

Nat Med ; 3(11): 1275-9, 1997 Nov.

Artigo Inglês | MEDLINE | ID: mdl-9359705

4.

Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage.

Wijnholds, J; Scheffer, G L; van der Valk, M; van der Valk, P; Beijnen, J H; Scheper, R J; Borst, P.

J Exp Med ; 188(5): 797-808, 1998 Sep 07.

Artigo Inglês | MEDLINE | ID: mdl-9730882

5.

Markedly increased risk of postoperative bleeding complications during perioperative bridging anticoagulation in general and visceral surgery.

Lock, J F; Ungeheuer, L; Borst, P; Swol, J; Löb, S; Brede, E M; Röder, D; Lengenfelder, B; Sauer, K; Germer, C-T.

Perioper Med (Lond) ; 9(1): 39, 2020 Nov 23.

Artigo Inglês | MEDLINE | ID: mdl-33292504

6.

Accumulation of replicative intermediates of mitochondrial DNA in Tetrahymena pyriformis grown in ethidium bromide.

Upholt, W B; Borst, P.

J Cell Biol ; 61(2): 383-97, 1974 May.

Artigo Inglês | MEDLINE | ID: mdl-4208072

7.

Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei.

Fairlamb, A H; Weislogel, P O; Hoeijmakers, J H; Borst, P.

J Cell Biol ; 76(2): 293-309, 1978 Feb.

Artigo Inglês | MEDLINE | ID: mdl-10605439

8.

Human multidrug resistance 3-P-glycoprotein expression in transgenic mice induces lens membrane alterations leading to cataract.

Dunia, I; Smit, J J; van der Valk, M A; Bloemendal, H; Borst, P; Benedetti, E L.

J Cell Biol ; 132(4): 701-16, 1996 Feb.

Artigo Inglês | MEDLINE | ID: mdl-8647899

9.

Programmed gene rearrangements altering gene expression.

Borst, P; Greaves, D R.

Science ; 235(4789): 658-67, 1987 Feb 06.

Artigo Inglês | MEDLINE | ID: mdl-3544215

10.

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.

Paulusma, C C; Bosma, P J; Zaman, G J; Bakker, C T; Otter, M; Scheffer, G L; Scheper, R J; Borst, P; Oude Elferink, R P.

Science ; 271(5252): 1126-8, 1996 Feb 23.

Artigo Inglês | MEDLINE | ID: mdl-8599091

11.

Genetic dissection of the function of mammalian P-glycoproteins.

Borst, P; Schinkel, A H.

Trends Genet ; 13(6): 217-22, 1997 Jun.

Artigo Inglês | MEDLINE | ID: mdl-9196326

12.

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Schinkel, A H; Wagenaar, E; van Deemter, L; Mol, C A; Borst, P.

J Clin Invest ; 96(4): 1698-705, 1995 Oct.

Artigo Inglês | MEDLINE | ID: mdl-7560060

13.

Platelet-activating factor: mediator of the third pathway of platelet aggregation? A study in three patients with deficient platelet-activating factor synthesis.

Sturk, A; Schaap, M C; ten Cate, J W; Heymans, H S; Schutgens, R B; Przyrembel, H; Borst, P.

J Clin Invest ; 79(2): 344-50, 1987 Feb.

Artigo Inglês | MEDLINE | ID: mdl-3805272

14.

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

Mayer, U; Wagenaar, E; Dorobek, B; Beijnen, J H; Borst, P; Schinkel, A H.

J Clin Invest ; 100(10): 2430-6, 1997 Nov 15.

Artigo Inglês | MEDLINE | ID: mdl-9366556

15.

Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy.

Crawford, A R; Smith, A J; Hatch, V C; Oude Elferink, R P; Borst, P; Crawford, J M.

J Clin Invest ; 100(10): 2562-7, 1997 Nov 15.

Artigo Inglês | MEDLINE | ID: mdl-9366571

16.

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

Evers, R; Kool, M; van Deemter, L; Janssen, H; Calafat, J; Oomen, L C; Paulusma, C C; Oude Elferink, R P; Baas, F; Schinkel, A H; Borst, P.

J Clin Invest ; 101(7): 1310-9, 1998 Apr 01.

Artigo Inglês | MEDLINE | ID: mdl-9525973

17.

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

Evers, R; Zaman, G J; van Deemter, L; Jansen, H; Calafat, J; Oomen, L C; Oude Elferink, R P; Borst, P; Schinkel, A H.

J Clin Invest ; 97(5): 1211-8, 1996 Mar 01.

Artigo Inglês | MEDLINE | ID: mdl-8636432

18.

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier.

Wijnholds, J; deLange, E C; Scheffer, G L; van den Berg, D J; Mol, C A; van der Valk, M; Schinkel, A H; Scheper, R J; Breimer, D D; Borst, P.

J Clin Invest ; 105(3): 279-85, 2000 Feb.

Artigo Inglês | MEDLINE | ID: mdl-10675353

19.

Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequences.

McCulloch, R; Rudenko, G; Borst, P.

Mol Cell Biol ; 17(2): 833-43, 1997 Feb.

Artigo Inglês | MEDLINE | ID: mdl-9001237

20.

Frequent loss of the active site during variant surface glycoprotein expression site switching in vitro in Trypanosoma brucei.

Cross, M; Taylor, M C; Borst, P.

Mol Cell Biol ; 18(1): 198-205, 1998 Jan.

Artigo Inglês | MEDLINE | ID: mdl-9418867

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