Detalhe da pesquisa
1.
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
Cell
; 184(20): 5089-5106.e21, 2021 09 30.
Artigo
Inglês
| MEDLINE | ID: mdl-34555357
2.
Synapses do not facilitate prion-like transfer of alpha-synuclein: a quantitative study in reconstructed unidirectional neural networks.
Cell Mol Life Sci
; 80(10): 284, 2023 Sep 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37688644
3.
Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates.
Neurobiol Dis
; 180: 106086, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36933673
4.
Clustering of Tau fibrils impairs the synaptic composition of α3-Na+/K+-ATPase and AMPA receptors.
EMBO J
; 38(3)2019 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30630857
5.
Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies.
J Immunol
; 207(8): 2143-2154, 2021 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34507948
6.
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
J Biol Chem
; 295(28): 9676-9690, 2020 07 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32467226
7.
Distinct alpha-Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH-SY5Y cells.
J Neurochem
; 156(6): 880-896, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32869336
8.
Probing amyloid fibril secondary structures by infrared nanospectroscopy: experimental and theoretical considerations.
Analyst
; 146(1): 132-145, 2021 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33107501
9.
Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice.
Int J Mol Sci
; 22(1)2021 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33401521
10.
Atomic Force Microscopy Imaging and Nanomechanical Properties of Six Tau Isoform Assemblies.
Biophys J
; 119(12): 2497-2507, 2020 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33217380
11.
Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs.
Biophys J
; 118(6): 1301-1320, 2020 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32059758
12.
Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.
EMBO J
; 35(19): 2120-2138, 2016 10 04.
Artigo
Inglês
| MEDLINE | ID: mdl-27550960
13.
Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces.
Biochem Biophys Res Commun
; 527(3): 760-769, 2020 06 30.
Artigo
Inglês
| MEDLINE | ID: mdl-32430178
14.
Dipeptide repeat derived from C9orf72 hexanucleotide expansions forms amyloids or natively unfolded structures in vitro.
Biochem Biophys Res Commun
; 526(2): 410-416, 2020 05 28.
Artigo
Inglês
| MEDLINE | ID: mdl-32223927
15.
Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.
Ann Neurol
; 86(4): 593-606, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31343083
16.
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.
Acta Neuropathol
; 139(6): 977-1000, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32356200
17.
α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.
J Neurochem
; 150(5): 522-534, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31254394
18.
Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification.
Neurobiol Dis
; 129: 38-43, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31078683
19.
α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.
EMBO J
; 34(19): 2408-23, 2015 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26323479
20.
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
Acta Neuropathol
; 137(6): 961-980, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30927072