Detalhe da pesquisa
1.
Multiple functional neurosteroid binding sites on GABAA receptors.
PLoS Biol
; 17(3): e3000157, 2019 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30845142
2.
Chemogenetic Isolation Reveals Synaptic Contribution of δ GABAA Receptors in Mouse Dentate Granule Neurons.
J Neurosci
; 38(38): 8128-8145, 2018 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30076210
3.
Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.
J Biol Chem
; 293(8): 3013-3027, 2018 02 23.
Artigo
Inglês
| MEDLINE | ID: mdl-29301936
4.
Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and δ subunits have opposite effects on surface expression.
Mol Pharmacol
; 86(1): 20-7, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24723490
5.
γ-aminobutyric acid type A α4, ß2, and δ subunits assemble to produce more than one functionally distinct receptor type.
Mol Pharmacol
; 86(6): 647-56, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25238745
6.
The Mechanism of Enantioselective Neurosteroid Actions on GABAA Receptors.
Biomolecules
; 13(2)2023 02 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36830708
7.
Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.
Mol Pharmacol
; 82(2): 255-63, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22572883
8.
A neurosteroid potentiation site can be moved among GABAA receptor subunits.
J Physiol
; 590(22): 5739-47, 2012 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22988137
9.
Functional characterization of the α5(Asn398) variant associated with risk for nicotine dependence in the α3ß4α5 nicotinic receptor.
Mol Pharmacol
; 80(5): 818-27, 2011 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-21856741
10.
Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site.
Mol Pharmacol
; 80(1): 79-86, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21498656
11.
Pharmacological and Biophysical Characteristics of Picrotoxin-Resistant, δSubunit-Containing GABAA Receptors.
Front Synaptic Neurosci
; 13: 763411, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34867260
12.
Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.
Mol Pharmacol
; 77(4): 539-46, 2010 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-20061447
13.
A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors.
J Pharmacol Exp Ther
; 333(2): 404-13, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20124410
14.
Site-specific effects of neurosteroids on GABAA receptor activation and desensitization.
Elife
; 92020 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32955433
15.
Steroid interaction with a single potentiating site is sufficient to modulate GABA-A receptor function.
Mol Pharmacol
; 75(4): 973-81, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19176850
16.
Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.
Mol Pharmacol
; 75(6): 1400-11, 2009 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-19289569
17.
Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1864(2): 128-136, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30471426
18.
The molecular determinants of neurosteroid binding in the GABA(A) receptor.
J Steroid Biochem Mol Biol
; 192: 105383, 2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31150831
19.
Mild chronic perturbation of inhibition severely alters hippocampal function.
Sci Rep
; 9(1): 16431, 2019 11 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31712706
20.
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
Mol Pharmacol
; 74(3): 614-27, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18544665