Frequency of attack in shock-elicited aggression as a function of the performance of individual rats.

Fighting rates between paired rats were investigated as a function of the probability of attack by a single animal. Animals from stable high-fighting and low-fighting frequency pairs were intermatched to detect individual high-fighting and low-fighting rats. Pairs of high-fighting animals then received saline or different chlorpromazine dosages during successive sessions. Finally, single high-fighting members of each pair also received the different drug dosages. The chief findings were that: (a) rats showing high fighting rates when matched against each other revealed low fighting rates when matched against one, but not the other member of a low-fighting pair; and (b) high-fighting rats decreased their fighting rates as their own or their opponent's chlorpromazine dosage increased. These results indicated that a low rate of fighting on the part of one rat results in a low fighting rate on the part of its opponent.

Vegan diet-based lifestyle program rapidly lowers homocysteine levels.

BACKGROUND: Plasma homocysteine levels have been directly associated with cardiac disease risk. Current research raises concerns as to whether comprehensive lifestyle approaches including a plant-based diet may interact with other known modulators of homocysteine levels. METHODS: We report our observations of homocysteine levels in 40 self-selected subjects who participated in a vegan diet-based lifestyle program. Each subject attended a residential lifestyle change program at the Lifestyle Center of America in Sulphur, Oklahoma and had fasting plasma total homocysteine measured on enrollment and then after 1 week of lifestyle intervention. The intervention included a vegan diet, moderate physical exercise, stress management and spirituality enhancement sessions, group support, and exclusion of tobacco, alcohol, and caffeine. B vitamin supplements known to reduce blood homocysteine levels were not provided. RESULTS: Subjects' mean homocysteine levels fell 13%: from 8.66 micromol/L (SD 2.7 micromol/L) to 7.53 micromol/L (SD 2.12 micromol/L; P < 0.0001). Subgroup analysis showed that homocysteine decreased across a range of demographic and diagnostic categories. Conclusions. Our results suggest that broad-based lifestyle interventions favorably impact homocysteine levels. Furthermore, analysis of Lifestyle Center of America program components suggests that other factors in addition to B vitamin intake may be involved in the observed homocysteine lowering.