Detalhe da pesquisa
1.
Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor.
Blood
; 142(1): 62-72, 2023 07 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36796019
2.
Intermittent treatment of BRAFV600E melanoma cells delays resistance by adaptive resensitization to drug rechallenge.
Proc Natl Acad Sci U S A
; 119(12): e2113535119, 2022 03 22.
Artigo
Inglês
| MEDLINE | ID: mdl-35290123
3.
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Nature
; 464(7287): 431-5, 2010 Mar 18.
Artigo
Inglês
| MEDLINE | ID: mdl-20130576
4.
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.
Proc Natl Acad Sci U S A
; 109(47): 19368-73, 2012 Nov 20.
Artigo
Inglês
| MEDLINE | ID: mdl-23134728
5.
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.
Nat Commun
; 13(1): 1450, 2022 03 18.
Artigo
Inglês
| MEDLINE | ID: mdl-35304457
6.
Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorg Med Chem Lett
; 21(4): 1243-7, 2011 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21251822
7.
Discovery and SAR of spirochromane Akt inhibitors.
Bioorg Med Chem Lett
; 21(8): 2410-4, 2011 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21392984
8.
The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.
Bioorg Med Chem Lett
; 21(4): 1248-52, 2011 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21211972
9.
Non-oxime pyrazole based inhibitors of B-Raf kinase.
Bioorg Med Chem Lett
; 21(11): 3488-92, 2011 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21536432
10.
Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.
Bioorg Med Chem Lett
; 21(8): 2335-40, 2011 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21420856
11.
Discovery of pyrrolopyrimidine inhibitors of Akt.
Bioorg Med Chem Lett
; 20(19): 5607-12, 2010 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20810279
12.
Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.
Bioorg Med Chem Lett
; 20(23): 7037-41, 2010 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20971641
13.
RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies.
J Thorac Oncol
; 15(4): 541-549, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31988000
14.
Inhibition and binding kinetics of the hepatitis C virus NS3 protease inhibitor ITMN-191 reveals tight binding and slow dissociative behavior.
Biochemistry
; 48(11): 2559-68, 2009 Mar 24.
Artigo
Inglês
| MEDLINE | ID: mdl-19209850
15.
Potent and selective pyrazole-based inhibitors of B-Raf kinase.
Bioorg Med Chem Lett
; 18(16): 4692-5, 2008 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18676143
16.
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor.
Clin Cancer Res
; 13(5): 1576-83, 2007 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17332304
17.
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
ACS Med Chem Lett
; 9(12): 1230-1234, 2018 Dec 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30613331
18.
Author Correction: The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.
Nat Commun
; 13(1): 1936, 2022 Apr 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35383193
19.
A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Cancer Discov
; 7(9): 963-972, 2017 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28578312
20.
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.
Cancer Cell
; 26(3): 402-413, 2014 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-25155755