RESUMO
PURPOSE: To evaluate the efficacy of intravitreal dexamethasone implant for the treatment of postoperative persistent cystoid macular edema (CME) following macular pucker surgery. METHODS: In this multicenter study, we retrospectively reviewed the data of 37 patients (39 eyes) who had been treated with intravitreal dexamethasone implant (Ozurdex®) for persistent CME following macular pucker surgery. Main outcome measures were change in best-corrected visual acuity (BCVA) and central retinal thickness (CRT). RESULTS: All eyes underwent spectral domain optical coherence tomography examination within 130 days after implantation. We observed a significant decrease in mean CRT from 519.9 to 392.9 µm (p < 0.0001). By this time, mean BCVA had improved from 0.60 to 0.43 logMAR (p = 0.003). Seventeen eyes (43.6%) required at least 1 repeat injection of dexamethasone. Of these, 8 (47%) eyes received a total number of 3 or more dexamethasone injections. CONCLUSION: Intravitreal dexamethasone implant injection is an effective treatment option for persistent CME following macular pucker surgery.
Assuntos
Dexametasona/administração & dosagem , Membrana Epirretiniana/cirurgia , Macula Lutea/patologia , Edema Macular/tratamento farmacológico , Complicações Pós-Operatórias , Vitrectomia/efeitos adversos , Idoso , Preparações de Ação Retardada , Implantes de Medicamento , Membrana Epirretiniana/diagnóstico , Feminino , Seguimentos , Glucocorticoides/administração & dosagem , Humanos , Injeções Intravítreas , Edema Macular/diagnóstico , Edema Macular/etiologia , Masculino , Estudos Retrospectivos , Fatores de Tempo , Tomografia de Coerência Óptica , Resultado do Tratamento , Acuidade VisualRESUMO
A common method to induce optical defocus is by means of positive lenses. However, accommodation, pupil size, and depth of focus are important factors determining the amount of defocus achieved. We therefore studied the effect of accommodation on visual acuity with a natural pupil (miosis) and in cycloplegic mydriasis. Additionally, we looked at the amount of accommodation and pupil size fluctuation during the recording of a mfVEP. We found that the amount of defocus induced with lenses of positive power is limited in non-mydriatic experiments by accommodation and actual pupil size and may show marked variation during mfVEP recording. We therefore recommend using a mydriatic drug and, if required, an artificial pupil for defocus experiments.