Detalhe da pesquisa
1.
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors.
Nat Chem Biol
; 2023 Oct 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37904048
2.
Functional metagenomic screening identifies an unexpected ß-glucuronidase.
Nat Chem Biol
; 18(10): 1096-1103, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35799064
3.
Combining experiment and energy landscapes to explore anaerobic heme breakdown in multifunctional hemoproteins.
Phys Chem Chem Phys
; 26(2): 695-712, 2024 Jan 03.
Artigo
Inglês
| MEDLINE | ID: mdl-38053511
4.
Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
J Biol Chem
; 296: 100101, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33214225
5.
Chain alignment of collagen I deciphered using computationally designed heterotrimers.
Nat Chem Biol
; 16(4): 423-429, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31907373
6.
Chemical probes targeting the kinase CK2: a journey outside the catalytic box.
Org Biomol Chem
; 19(20): 4380-4396, 2021 05 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34037044
7.
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study.
Molecules
; 26(7)2021 Mar 31.
Artigo
Inglês
| MEDLINE | ID: mdl-33807474
8.
Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa.
J Biol Chem
; 294(42): 15505-15516, 2019 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-31484721
9.
Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa.
J Biol Chem
; 293(37): 14260-14269, 2018 09 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30030382
10.
Novel non-ATP competitive small molecules targeting the CK2 α/ß interface.
Bioorg Med Chem
; 26(11): 3016-3020, 2018 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29759799
11.
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
Bioorg Med Chem
; 25(13): 3471-3482, 2017 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28495381
12.
Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.
Org Biomol Chem
; 11(16): 2660-75, 2013 Apr 28.
Artigo
Inglês
| MEDLINE | ID: mdl-23467665
13.
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture.
Nat Commun
; 14(1): 768, 2023 02 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36765057
14.
Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur J Med Chem
; 250: 115177, 2023 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36753880
15.
Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control.
Front Microbiol
; 14: 1195558, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37250041
16.
Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2.
J Med Chem
; 66(14): 9881-9893, 2023 07 27.
Artigo
Inglês
| MEDLINE | ID: mdl-37433017
17.
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Nat Commun
; 14(1): 3583, 2023 06 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37328472
18.
Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.
Chembiochem
; 13(16): 2374-83, 2012 Nov 05.
Artigo
Inglês
| MEDLINE | ID: mdl-23070966
19.
Crystal structure of the Rho-associated coiled-coil kinase 2 inhibitor belumosudil bound to CK2α.
Acta Crystallogr F Struct Biol Commun
; 78(Pt 10): 348-353, 2022 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36189718
20.
Systems-Wide Dissection of Organic Acid Assimilation in Pseudomonas aeruginosa Reveals a Novel Path To Underground Metabolism.
mBio
; 13(6): e0254122, 2022 12 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36377867