Pesquisa | Secretaria de Estado da Saúde

1.

Engineering Cancer Antigen-Specific T Cells to Overcome the Immunosuppressive Effects of TGF-ß.

Silk, Jonathan D; Abbott, Rachel J M; Adams, Katherine J; Bennett, Alan D; Brett, Sara; Cornforth, Terri V; Crossland, Katherine L; Figueroa, David J; Jing, Junping; O'Connor, Caitriona; Pachnio, Annette; Patasic, Lea; Peredo, Carlos E; Quattrini, Adriano; Quinn, Laura L; Rust, Alistair G; Saini, Manoj; Sanderson, Joseph P; Steiner, Dylan; Tavano, Barbara; Viswanathan, Preetha; Wiedermann, Guy E; Wong, Ryan; Jakobsen, Bent K; Britten, Cedrik M; Gerry, Andrew B; Brewer, Joanna E.

J Immunol ; 208(1): 169-180, 2022 01 01.

Artigo Inglês | MEDLINE | ID: mdl-34853077

2.

Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects - a randomized, double-blind, placebo-controlled study.

Ellis, Joanne; van Maurik, Andre; Fortunato, Lea; Gisbert, Sophie; Chen, Keguan; Schwartz, Ann; McHugh, Simon; Want, Andrew; Santos Franco, Sara; Oliveira, Joao-Joaquim; Price, Jeffrey; Coles, Alasdair; Brown, Kim; Su, Donggang; Craigen, Jenny L; Yang, Jiansong; Brett, Sara; Davis, Bill; Cheriyan, Joseph; Kousin-Ezewu, Onajite; Gray, Frank; Thompson, Paul W; Fernando, Disala.

Br J Clin Pharmacol ; 85(2): 304-315, 2019 02.

Artigo Inglês | MEDLINE | ID: mdl-30161291

3.

CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6⁺ cells in an experimental suction blister.

Bouma, Gerben; Zamuner, Stefano; Hicks, Kirsty; Want, Andrew; Oliveira, João; Choudhury, Arpita; Brett, Sara; Robertson, Darren; Felton, Leigh; Norris, Virginia; Fernando, Disala; Herdman, Michael; Tarzi, Ruth.

Br J Clin Pharmacol ; 83(9): 1976-1990, 2017 Sep.

Artigo Inglês | MEDLINE | ID: mdl-28295451

4.

Characterisation of the clinical and activated T cell response to repeat delayed-type hypersensitivity skin challenges in human subjects, with KLH and PPD, as a potential model to test T cell-targeted therapies.

Belson, Alexandra; Schmidt, Tim; Fernando, Disala; Hardes, Kelly; Scott, Nicola; Brett, Sara; Clark, Deborah; Oliveira, João Joaquim; Davis, Bill; McHugh, Simon; Stone, John.

Inflamm Res ; 65(5): 389-404, 2016 May.

Artigo Inglês | MEDLINE | ID: mdl-26969026

5.

Immuno-PET Monitoring of CD8⁺ T Cell Infiltration Post ICOS Agonist Antibody Treatment Alone and in Combination with PD-1 Blocking Antibody Using a ⁸⁹Zr Anti-CD8⁺ Mouse Minibody in EMT6 Syngeneic Tumor Mouse.

Alsaid, Hasan; Cheng, Shih-Hsun; Bi, Meixia; Xie, Fang; Rambo, Mary; Skedzielewski, Tinamarie; Hoang, Bao; Mohanan, Sunish; Comroe, Debra; Gehman, Andrew; Hsu, Chih-Yang; Farhangi, Kamyar; Tran, Hoang; Sherina, Valeriia; Doan, Minh; Groseclose, M Reid; Hopson, Christopher B; Brett, Sara; Wilson, Ian A; Nicholls, Andrew; Ballas, Marc; Waight, Jeremy D; Jucker, Beat M.

Mol Imaging Biol ; 25(3): 528-540, 2023 06.

Artigo Inglês | MEDLINE | ID: mdl-36266600

6.

Activating Inducible T-cell Costimulator Yields Antitumor Activity Alone and in Combination with Anti-PD-1 Checkpoint Blockade.

Yadavilli, Sapna; Waight, Jeremy D; Brett, Sara; Bi, Meixia; Zhang, Tianqian; Liu, Yao-Bin; Ellis, Catherine; Turner, David C; Hahn, Ashleigh; Shi, Hong; Seestaller-Wehr, Laura; Jing, Junping; Xie, Qing; Shaik, Jafar Sadik; Ji, Xiao; Gagnon, Robert; Fieles, William; Hook, Laura; Grant, Steven; Hopley, Stephanie; DeYoung, M Phillip; Blackwell, Christina; Chisamore, Michael; Biddlecombe, Robert; Figueroa, David J; Hopson, Christopher B; Srinivasan, Roopa; Smothers, James; Maio, Michele; Rischin, Danny; Olive, Daniel; Paul, Elaine; Mayes, Patrick A; Hoos, Axel; Ballas, Marc.

Cancer Res Commun ; 3(8): 1564-1579, 2023 08.

Artigo Inglês | MEDLINE | ID: mdl-37593752

7.

Induction of homologous rather than heterologous antigen-specific CD4 T cell responses is critical for functional CD8 T cell responses in mice transgenic for a foreign antigen.

Sabarth, Nicolas; Chamberlain, Louise; Brett, Sara; Tite, John; Craigen, Jenny.

J Immunol ; 185(8): 4590-601, 2010 Oct 15.

Artigo Inglês | MEDLINE | ID: mdl-20861346

8.

Characterization of the robust humoral immune response to GSK2618960, a humanized anti-IL-7 receptor monoclonal antibody, observed in healthy subjects in a Phase 1 study.

Liao, Karen; Chen, Keguan; Brett, Sara; Gehman, Andrew; Schwartz, Ann M; Gunn, George R; DeWall, Stephen L.

PLoS One ; 16(3): e0249049, 2021.

Artigo Inglês | MEDLINE | ID: mdl-33755713

9.

Depletion of LAG-3⁺ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781.

Ellis, Joanne; J B Marks, Daniel; Srinivasan, Naren; Barrett, Christine; Hopkins, Thomas G; Richards, Anna; Fuhr, Rainard; Albayaty, Muna; Coenen, Martin; Liefaard, Lia; Leavens, Karen; Nevin, Katherine L; Tang, Shuo; Hughes, Stephen A; Fortunato, Léa; Edwards, Ken; Cui, Yi; Anselm, Rabia; Delves, Christopher J; Charles, Emilie; Feeney, Maria; Webb, Thomas M; Brett, Sara J; Schmidt, Tim S; Stone, John; Savage, Caroline O S; Wisniacki, Nicolas; Tarzi, Ruth M.

Clin Pharmacol Ther ; 109(5): 1293-1303, 2021 05.

Artigo Inglês | MEDLINE | ID: mdl-33113155

10.

Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion.

Evans, Alexander; Riva, Antonio; Cooksley, Helen; Phillips, Sandra; Puranik, Smrithi; Nathwani, Amit; Brett, Sara; Chokshi, Shilpa; Naoumov, Nikolai V.

Hepatology ; 48(3): 759-69, 2008 Sep.

Artigo Inglês | MEDLINE | ID: mdl-18697210

11.

High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer.

Massarelli, Erminia; Lam, Vincent K; Parra, Edwin R; Rodriguez-Canales, Jaime; Behrens, Carmen; Diao, Lixia; Wang, Jing; Blando, Jorge; Byers, Lauren A; Yanamandra, Niranjan; Brett, Sara; Morley, Peter; Sharma, Padmanee; Allison, James; Wistuba, Ignacio I; Heymach, John V.

J Immunother Cancer ; 7(1): 351, 2019 12 16.

Artigo Inglês | MEDLINE | ID: mdl-31843013

12.

Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments.

Yu, Jong W; Bhattacharya, Sabyasachi; Yanamandra, Niranjan; Kilian, David; Shi, Hong; Yadavilli, Sapna; Katlinskaya, Yuliya; Kaczynski, Heather; Conner, Michael; Benson, William; Hahn, Ashleigh; Seestaller-Wehr, Laura; Bi, Meixia; Vitali, Nicholas J; Tsvetkov, Lyuben; Halsey, Wendy; Hughes, Ashley; Traini, Christopher; Zhou, Hui; Jing, Junping; Lee, Tae; Figueroa, David J; Brett, Sara; Hopson, Christopher B; Smothers, James F; Hoos, Axel; Srinivasan, Roopa.

PLoS One ; 13(11): e0206223, 2018.

Artigo Inglês | MEDLINE | ID: mdl-30388137

13.

Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials.

Choy, Ernest H; Bendit, Marina; McAleer, Dana; Liu, Feng; Feeney, Maria; Brett, Sara; Zamuner, Stefano; Campanile, Andrea; Toso, John.

Arthritis Res Ther ; 15(5): R132, 2013 Sep 24.

Artigo Inglês | MEDLINE | ID: mdl-24286335

14.

Development of an Escherichia coli expressing listeriolysin-O vaccine against Wilms tumor gene 1-expressing tumors.

Dai, Ming-Shen; Nitcheu-Tefit, Josianne; Alcock, Sally; Ramirez-Jimenez, Francisco; Chao, Tsu-Yi; Baril, Patrick; Rocha, Marian; Brett, Sara J; Stauss, Hans J; Vassaux, Georges.

J Immunother ; 32(8): 845-55, 2009 Oct.

Artigo Inglês | MEDLINE | ID: mdl-19752749

15.

Perturbation of naive TCR transgenic T cell functional responses and upstream activation events by anti-CD4 monoclonal antibodies.

Fehérvári, Zoltán; Cooke, Anne; Brett, Sara; Turner, Julia.

Eur J Immunol ; 32(2): 333-40, 2002 02.

Artigo Inglês | MEDLINE | ID: mdl-11807772

16.

Infection of mouse bone marrow-derived dendritic cells with recombinant adenovirus vectors leads to presentation of encoded antigen by both MHC class I and class II molecules-potential benefits in vaccine design.

Herrera, Osquel Barroso; Brett, Sara; Lechler, Robert I.

Vaccine ; 21(3-4): 231-42, 2002 Dec 13.

Artigo Inglês | MEDLINE | ID: mdl-12450698

17.

Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery.

Thomsen, Lindy L; Topley, Peter; Daly, Maria G; Brett, Sara J; Tite, John P.

Vaccine ; 22(13-14): 1799-809, 2004 Apr 16.

Artigo Inglês | MEDLINE | ID: mdl-15068864

18.

Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming.

Martín-Fontecha, Alfonso; Thomsen, Lindy L; Brett, Sara; Gerard, Craig; Lipp, Martin; Lanzavecchia, Antonio; Sallusto, Federica.

Nat Immunol ; 5(12): 1260-5, 2004 Dec.

Artigo Inglês | MEDLINE | ID: mdl-15531883

19.

Characterization of CC-chemokine receptor 7 expression on murine T cells in lymphoid tissues.

Bjorkdahl, Olle; Barber, Karen A; Brett, Sara J; Daly, Maria G; Plumpton, Christopher; Elshourbagy, Nabil A; Tite, John P; Thomsen, Lindy L.

Immunology ; 110(2): 170-9, 2003 Oct.

Artigo Inglês | MEDLINE | ID: mdl-14511230

20.

Limiting dilution analysis of the human T cell response to mycobacterial antigens from BCG vaccinated individuals and leprosy patients

Brett, Sara J.

s.l; s.n; 1987. 11 p. tab, graf.

Não convencional Inglês | SES-SP, HANSEN, Hanseníase, SES SP = Acervo Instituto Lauro de Souza Lima, SES-SP | ID: biblio-1231464

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