Long-term mortality after internal fixation of calcaneal fractures: a retrospective study.

The aim of this study was to describe the mortality risk after calcaneal fractures which required internal fixation and evaluate predictors of survival. During the observed 11-year period (1995-2006), 178 consecutive patients underwent operative fixation for displaced intra-articular calcaneal fractures. Patient demographics, mechanism of injury, and social deprivation (Carstairs index) were recorded. Mortality was obtained from patient notes. Causes of mortality were obtained from the national database. Standardised mortality ratios (SMRs) were calculated. Ten patients were lost to follow-up. Of the remaining 168 patients, the mean age was 41 (range 14-77) years. Females [n = 33, 46.3 standard deviation (SD) 17.1 years] were significantly (difference 6.5 years, 95% CI 1.1-11.9, p = 0.02) older than male patients (n = 135, 39.8 SD 13.4 years). During the study period, 28 patients died. The overall unadjusted survival rate was 92.8% (95% CI 87.0-98.7) at 10 years and 81.9% (95% CI 76.2-87.6) at 15 years. The SMR at 10 years was 5.2 (95% CI 2.8-13.3) for males and 1.4 (95% CI - 4.9 to 7.8) for females. Cox regression analysis demonstrated male gender to be a significant predictor of mortality (hazard ratio 2.77, 95% 3.83-9.65, p = 0.01) adjusted for age and social deprivation. Male patients requiring internal fixation of intra-articular calcaneal fractures have a significantly increased mortality risk compared to an age- and gender-matched population. Further study is warranted to fully identify the reasons behind this, which may enable their survival to be improved.Level of evidence Retrospective Cohort study, Level 4.

Lower Rates of Staphylococcus aureus Bloodstream Infection in Patients on Hemodialysis Receiving Trimethoprim-Sulfamethoxazole Melioidosis Prophylaxis.

Hemodialysis is a risk factor for Staphylococcus aureus bloodstream infection (SAB). In this single-center study, SAB rates were 56% lower during the monsoonal wet season when patients on hemodialysis receive supervised melioidosis prophylaxis with trimethoprim-sulfamethoxazole. This intervention may reduce SAB rates in high-risk patients; however, further targeted studies are required.

Engagement and partnership with consumers and communities in the co-design and conduct of Research: Lessons from the INtravenous iron polymaltose for First Nations Australian patients with high FERRitin levels on haemodialysis (INFERR) clinical trial.

BACKGROUND: Engagement and partnership with consumers and communities throughout research processes produces high quality research meeting community needs and promoting translation of research into improved policy and practice. Partnership is critical in research involving Aboriginal and/or Torres Strait Islander people (First Nations Peoples) to ensure cultural safety. We present lessons from the design, implementation and progress of the National Health and Medical Research Council funded INtravenous iron polymaltose for First Nations Australian patients with high FERRitin levels on hemodialysis (INFERR) clinical trial. MAIN BODY: The trial was designed to understand the benefits and harms of iron therapy in First Nations Australians on haemodialysis with anaemia and hyperferritinaemia. The lack of evidence for treatment was discussed with patients who were potential participants. A key element ensuring safe conduct of the INFERR trial was the establishment of the Indigenous Reference Groups (IRGs) comprising of dialysis patients based in the Top End of Australia and Central Australia. Two IRGs were needed based on advice from First Nations communities and researchers/academics on the project regarding local cultural differences and approaches to trial conduct. The IRGs underpin culturally safe trial conduct by providing input into study materials and translating study findings into effective messages and policies for First Nations dialysis patients. Throughout the trial conduct, the IRGs' role has developed to provide key mechanisms for advice and guidance regarding research conduct both in this study and more broadly. Support provided to the IRGs by trial First Nations Research Officers and independent First Nations researchers/academics who simplify research concepts is critical. The IRGs have developed feedback documents and processes to participants, stakeholders, and the renal units. They guarantee culturally safe advice for embedding findings from the trial into clinical practice guidelines ensuring evidence-based approaches in managing anaemia in haemodialysis patients with hyperferritinaemia. CONCLUSION: Active consumer and community partnership is critical in research conduct to ensure research impact. Strong partnership with consumers in the INFERR clinical trial has demonstrated that First Nations Consumers will engage in research they understand, that addresses health priorities for them and where they feel respected, listened to, and empowered to achieve change.

In this paper, we present the importance of actively involving consumers in the planning, implementation and conduct of research using the example of a clinical trial among Aboriginal and/or Torres Strait Australians (First Nations Australians) who have kidney disease and are currently receiving haemodialysis. The study assesses how safe and effective it is for people on dialysis to receive iron given through the vein during dialysis when they have anaemia and high levels of a blood test called ferritin, a test used routinely to measure iron levels. Two consumer reference groups of First Nations patients on dialysis, one based in the Top End of Australia and the other based in Central Australia, are supported by First Nations Research Officers and Research Academics to make sure that the research is performed in a way that involves, respects and values First Nations participation, culture, and knowledge. Active consumer and community partnership in this study has supported robust research governance processes which we believe are crucial for knowledge translation to have a positive impact for patients.