Detalhe da pesquisa
1.
A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.
J Biol Chem
; 285(24): 18516-27, 2010 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-20378535
2.
Cruzain : the path from target validation to the clinic.
Adv Exp Med Biol
; 712: 100-15, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-21660661
3.
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
J Biol Chem
; 284(38): 25697-703, 2009 Sep 18.
Artigo
Inglês
| MEDLINE | ID: mdl-19620707
4.
The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin.
Mol Biochem Parasitol
; 164(1): 86-94, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19111576
5.
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
Bioorg Med Chem Lett
; 19(21): 6218-21, 2009 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19773167
6.
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Structure
; 15(5): 535-43, 2007 May.
Artigo
Inglês
| MEDLINE | ID: mdl-17502099
7.
Can mosquitoes be bitten? A new hope for anti-malarial drug design.
Structure
; 11(11): 1309-10, 2003 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-14604516
8.
Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica.
Mol Biochem Parasitol
; 119(1): 23-32, 2002 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-11755183
9.
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
PLoS Negl Trop Dis
; 4(9)2010 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-20856868
10.
Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
PLoS Negl Trop Dis
; 4(6): e701, 2010 Jun 08.
Artigo
Inglês
| MEDLINE | ID: mdl-20544024
11.
Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.
J Med Chem
; 53(4): 1763-73, 2010 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-20088534
12.
Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution.
Proteins
; 56(1): 171-5, 2004 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15162497
13.
Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution.
Proteins
; 54(1): 157-61, 2004 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-14705032
14.
Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution.
Proteins
; 54(1): 174-7, 2004 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-14705036
15.
Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution.
Proteins
; 54(4): 806-9, 2004 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-14997578
16.
Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution.
Proteins
; 54(4): 801-5, 2004 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-14997577
17.
Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold.
Proteins
; 56(3): 607-10, 2004 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15229892
18.
Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution.
Proteins
; 56(2): 396-400, 2004 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15211524
19.
Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution.
Proteins
; 49(1): 142-5, 2002 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12211025
20.
Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution.
Proteins
; 53(1): 142-5, 2003 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-12945057