RESUMO
A 27-year-old woman in the second trimester of pregnancy presented with bitemporal hemianopsia. Total resection of a craniopharyngioma restored normal vision, and she delivered a normal infant at term. Permanent hormonal replacement therapy was not needed. Subsequent spontaneous pregnancy and delivery indicate that fertility was preserved. Literature review shows this case to be unique. Even with new developments in stereotactic radiotherapy, total excision remains a potentially achievable surgical goal.
Assuntos
Craniofaringioma/fisiopatologia , Fertilidade , Neoplasias Hipofisárias/fisiopatologia , Complicações Neoplásicas na Gravidez/fisiopatologia , Adulto , Craniofaringioma/cirurgia , Feminino , Humanos , Neoplasias Hipofisárias/cirurgia , Gravidez , Complicações Neoplásicas na Gravidez/cirurgiaAssuntos
Anidridos/metabolismo , Antineoplásicos/metabolismo , Citarabina/metabolismo , Leucemia/tratamento farmacológico , Anidridos/administração & dosagem , Anidridos/sangue , Anidridos/toxicidade , Anidridos/urina , Animais , Antineoplásicos/administração & dosagem , Antineoplásicos/sangue , Antineoplásicos/toxicidade , Antineoplásicos/urina , Isótopos de Carbono , Cromatografia por Troca Iônica , Cromatografia em Papel , Citarabina/administração & dosagem , Citarabina/sangue , Citarabina/toxicidade , Citarabina/urina , Eletroforese , Feminino , Camundongos , Camundongos Endogâmicos DBA , Fosfatos/análise , Ratos , Fatores de TempoAssuntos
Condicionamento Psicológico/efeitos dos fármacos , Cyprinidae , Extinção Psicológica/efeitos dos fármacos , Memória/efeitos dos fármacos , Puromicina/farmacologia , Animais , Aprendizagem da Esquiva/efeitos dos fármacos , Eletrochoque , Concentração de Íons de Hidrogênio , Aprendizagem/efeitos dos fármacos , Masculino , Memória de Curto Prazo/efeitos dos fármacos , Ratos , Esquema de Reforço , Fatores de TempoRESUMO
A U.S. farm policy shift to joint production of commodities and ecological services will advance sustainable agriculture.
Assuntos
Agricultura , Biomassa , Conservação dos Recursos Naturais , Meio Ambiente , Agricultura/economia , Agricultura/legislação & jurisprudência , Conservação dos Recursos Naturais/economia , Conservação dos Recursos Naturais/legislação & jurisprudência , Produtos Agrícolas , Ecossistema , Fontes Geradoras de Energia , Política Pública , Pesquisa , Estados UnidosRESUMO
Two water-soluble gels, gelatin and Carbowax, were mixed with radioactive 68Ge solutions and evaluated for their use as long-lived (half-life, 280 days) radioactive sources. These gels melt at 40-50 degrees C and solidify at room temperature. The amount of 68Ge mixed with them can be increased or decreased as needed, eliminating waste of 68Ge. These gel sources also may replace short-lived 68Ga (half-life 68 min) as attenuation correction sources in positron emission tomography (PET) and reduce frequency of source preparation, thus reducing exposure of PET operators to radiation.
Assuntos
Gelatina , Germânio/química , Radioisótopos/química , Ceras , Géis , Temperatura , Tomografia Computadorizada de EmissãoRESUMO
BACKGROUND: An increasing number of patients with breast cancer is being treated with preoperative chemotherapy. Evaluation of treatment response may be facilitated by positron emission tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (FDG). This noninvasive technique may allow prediction of the chemotherapy outcome in an early phase of the treatment. METHODS: Prerequisites for treatment monitoring with PET are good FDG uptake in the tumor, high specificity, and a reliable quantification technique. These factors were studied in 20 patients with primary breast cancer, lymph node metastases, benign breast lesions, a combination of these abnormalities, or no abnormality. RESULTS: In 10 of 11 patients with primary breast cancer, the tumor was visualized. The median tumor-to-normal-tissue-uptake ratio was 4.9. In all five patients with increased uptake in the lymph node basin, pathologic proof of metastatic cancer was found. Of the patients with benign or no disease of the breast, slightly increased uptake was seen in one patient with fibrocystic disease. CONCLUSION: It is concluded that PET with FDG can be used for breast cancer imaging and staging.