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OBJECTIVES: To evaluate the long-term efficacy of treating nasal telangiectasias with the TRASER device. METHODS: Subjects from the TRASER efficacy analysis clinical trial were invited for a 1-year follow-up. Standardized photographs were taken to compare to baseline. The same clinical trial evaluator graded the subjects' current vessel clearance using the 5-point telangiectasia scale. The data was compiled and analyzed. RESULTS: Of the subjects with available follow-up data, 44% maintained "complete vessel clearance," 44% dropped down one grade to "almost complete vessel clearance," and 11% dropped down to "moderately clear vessel clearance." All showed clinically significant improvement in nasal telangiectasias from baseline. CONCLUSIONS: The TRASER effectively treats nasal telangiectasias with minimal to mild recurrence at 1-year follow-up. Lasers Surg. Med. 50:61-63, 2018. © 2017 Wiley Periodicals, Inc.
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Lasers de Corante/uso terapêutico , Nariz , Telangiectasia/radioterapia , Seguimentos , Humanos , Telangiectasia/patologia , Fatores de Tempo , Resultado do TratamentoRESUMO
BACKGROUND: Among the most vulnerable people in society are children and this is especially so in their access to health care Off-label prescription of paediatric medicines is known to be associated with safety outcomes some of which may be serious. This study identifies frequently prescribed children's medicines that are not readily available in Ghana and are prepared extemporaneously. METHOD: All prescriptions for extemporaneous oral preparations for children presented to the local production unit of the Korle-Bu Teaching Hospital from November, 2013 were eligible for the study. Information from such prescriptions was recorded in a systematic format. Presence of the prescribed medicine on the World Health Organization Children's Medicine List was ascertained in addition to the anatomical and therapeutic classification code. The registration of the prescribed medicine for paediatric use by the Food and Drugs Authority, Ghana was also checked. Descriptive statistics of the data was presented. RESULTS: In all 622 prescriptions for 35 different paediatric formulations were served. Prescriptions from several health facilities including government hospitals (6.6 %, N = 622), private hospitals (2.4 %, N = 622) and the University of Ghana hospital (1.1 %, N = 622) were all honoured. Some of the prescribed medicines (Baclofen, Clonazepam, Hydroxyurea and Lamotrigine) were neither on the World Health Organization Children's Medicine list nor registered with the Food and Drugs Authority, Ghana. Most prescribed medicines (88.6 %, N = 35) were for non-communicable diseases. CONCLUSION: Paediatric prescriptions including off-label medicines are prescribed and formulated extemporaneously in this setting. Steps should be taken to improve access and monitor benefit-risk profiles of paediatric medicines in order to improve treatment outcomes among children.
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Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Medicamentos sob Prescrição/provisão & distribuição , Administração Oral , Criança , Pré-Escolar , Feminino , Gana , Hospitais de Ensino , Humanos , Lactente , Recém-Nascido , Masculino , Uso Off-Label , Medicamentos sob Prescrição/administração & dosagemAssuntos
Fracionamento da Dose de Radiação , Lasers , Terapia com Luz de Baixa Intensidade/métodos , Nevo/radioterapia , Neoplasias Cutâneas/radioterapia , Biópsia , Face , Feminino , Humanos , Terapia com Luz de Baixa Intensidade/instrumentação , Pescoço , Nevo/patologia , Pele/patologia , Pele/efeitos da radiação , Neoplasias Cutâneas/patologia , Resultado do Tratamento , Adulto JovemRESUMO
BACKGROUND: New findings are emerging about parental perceptions and desires for involvement in infant pain management in the neonatal intensive care unit (NICU) setting, and the importance of building greater knowledge about this aspect of the patient care is beginning to be appreciated. OBJECTIVES: The study had two aims: (a) to describe perceptions and feelings of parents who participated in a randomized controlled trial of an intervention to increase parent knowledge and involvement in infant pain management; and (b) to further refine the conceptual representation of the parental experience of involvement in infant pain management (or lack thereof) and the influencing factors. METHODS: Thematic analysis was used to explore the content of parents' written comments and to integrate the present and previous research findings. RESULTS: Parents expressed strong preferences for more information about all aspects of infant pain care, improved timing of information giving, and involvement opportunities. They further desired increased sensitivity and consistency in infant care giving and increased use of specific pain-relieving interventions by NICU staff. Contextual factors such as parents' emotional state and the communication and support from NICU staff influenced parents' ability to achieve their desired level of involvement. DISCUSSION: The role of parents in infant pain management is a relatively new area of research. The discussion of conceptual models to guide research and practice is an important milestone representing new opportunity for further scientific developments with important clinical implications for the nursing care of critically ill infants and their families. CLINICAL RELEVANCE: New data continue to emerge about parental perceptions and desires for involvement in infant pain management. A new empirically based model may be useful to nurses in providing optimal pain management for NICU infants in partnership with parents.
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Atitude Frente a Saúde , Terapia Intensiva Neonatal/métodos , Manejo da Dor/métodos , Relações Pais-Filho , Pais/psicologia , Pesquisa Empírica , Humanos , Recém-Nascido , Unidades de Terapia Intensiva Neonatal , Pais/educação , Relações Profissional-Família , Inquéritos e QuestionáriosRESUMO
BACKGROUND: Bariatric surgery is an effective means of managing weight and reducing medical co-morbidities in the obese patient. However, psychological difficulties are common and adequate multidisciplinary support is vital for post-surgical success. Videoconferencing is potentially a vehicle for the delivery of support to patients residing in remote areas. METHODS: Ten patients were invited to attend a videolink session utilising videoconferencing technology to allow clinicians to connect audio-visually with patients from two remote locations. Seven patients attended. A Consultant Surgeon, Clinical Psychologist and Specialist Dietitian reviewed the patients. Patients and clinicians completed a post-session evaluation questionnaire and commented on their experience. RESULTS: The videolink session was evaluated as acceptable and useful to both patients and clinicians. Patients and clinicians were satisfied with the user-friendliness of the technology. CONCLUSION: Videolink technology may be a viable and accessible means of delivering specialist multidisciplinary input to bariatric patients. Further research is necessary.
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The first comprehensive point prevalence survey at the Korle Bu Teaching Hospital (KBTH) was performed as part of the 2019 Global Point Prevalence Survey (Global-PPS) on antimicrobials. The aim was to establish a PPS baseline for the whole hospital and to identify required stewardship interventions. The PPS was conducted over three days in June 2019 using the GLOBAL-PPS standardized method for surveillance of antimicrobial utilization in hospitals to evaluate antimicrobial prescribing. In all, 988 patients were admitted to 69 wards. Overall antimicrobial prevalence was 53.3%. More community-acquired infections (CAI) were treated empirically compared to health-care associated infections (94.0% vs. 86.1% respectively, p = 0.002). Main indications for prescribing antimicrobials were pneumonia (18.4%), skin and soft tissue infections (11.4%) and sepsis (11.1%). Among antimicrobials, systemic antibiotics accounted for 83.5%, of which amoxicillin with beta-lactam inhibitor (17.5%), metronidazole (11.8%) and ceftriaxone (11.5%) dominated. Guideline compliance was 89.0%. Stop/review dates were completed in 33.4% and documented reason was recorded in 53.0% of all prescriptions. If the findings in this PPS can be addressed antimicrobial stewardship at the KBTH stands to improve significantly.
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BACKGROUND AND OBJECTIVES: Patients who received NCA with morphine following major surgery between 1996 and 2008 at Great Ormond Street Hospital, London, UK, were prospectively studied in the postoperative period to determine effectiveness, morphine requirements, incidence of common side effects, and serious adverse events. METHODS: The morphine NCA regimen and monitoring was according to standard hospital protocols. Data were collected prospectively and subsequently entered by trained personnel into a secure database. Patient demographics, effectiveness and satisfaction rates, morphine requirements, side effects, and serious complications were recorded. RESULTS: 10,079 patients were included. The average age was 4 years old (range 1 day to 20.5 years, median 2.3 years). There were 510 neonates. The average NCA duration was 43.7 h. 1.8% of morphine NCAs were replaced by other methods because analgesia was unsatisfactory. Satisfaction ratings were 'good' or 'very good' for 98% of the remainder. Average daily morphine requirement (mcg x kg(-1) x h(-1)) was related to age, surgical category, and postoperative time. Side effects included PONV (25%), itching (9.4%), depression of respiration, and sedation (4.5%); incidences varied with age, morphine dose, and type of surgery. Serious, potentially life-threatening adverse effects (SAE) were 0.4%. There were no deaths. SAE were significantly greater in neonates (2.5%), relative risk 9.4, P < 0.001. Morphine dose in neonates who experienced SAE was not significantly different from other neonates. CONCLUSION: NCA with morphine is an acceptable, safe, and effective method of postoperative analgesia for a wide range of ages and types of surgery in our practice. Morphine requirements increase with age, but there was also considerable inter-individual variation within age groups. PONV, itching, sedation, and respiratory depression are expected side effects. SAE are uncommon but the incidence is greatest in neonates.
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Analgesia/métodos , Enfermeiras e Enfermeiros , Dor Pós-Operatória/tratamento farmacológico , Adolescente , Analgesia/efeitos adversos , Analgésicos Opioides/administração & dosagem , Analgésicos Opioides/efeitos adversos , Analgésicos Opioides/uso terapêutico , Criança , Pré-Escolar , Competência Clínica , Interpretação Estatística de Dados , Feminino , Hospitais Pediátricos , Humanos , Lactente , Recém-Nascido , Masculino , Monitorização Fisiológica , Medição da Dor , Náusea e Vômito Pós-Operatórios/epidemiologia , Prurido/induzido quimicamente , Prurido/epidemiologia , Insuficiência Respiratória/induzido quimicamente , Insuficiência Respiratória/epidemiologia , Resultado do TratamentoRESUMO
OBJECTIVE: To explore some of the reasons for poor compliance with the use of standardized pain assessment tools in clinical practice, despite numerous guidelines and standards mandating their use. METHODS: First, a review of research and clinical audit literature on the effects of standardized pain assessment tools on patient or process outcomes was conducted, and findings were critiqued. Second, a synthesis of recent literature on the biopsychosocial mechanisms of human detection and recognition of pain in others was presented. Third, the implications for pain assessment in pediatric clinical settings were discussed. RESULTS: There is a lack of good-quality evidence for the efficacy, effectiveness or cost-benefit of standardized pain assessment tools in relation to pediatric patient or process outcomes. Research suggests that there may be greater variability than previously appreciated in the ability and motivation of humans when assessing pain in others. It remains unknown whether pain detection skills or motivation to relieve pain in others can be improved or overcome by standardized methods of pain assessment. DISCUSSION: Further research is needed to understand the intra- and interpersonal dynamics in clinical assessment of pain in children and to test alternative means of achieving diagnosis and treatment of pain. Until this evidence is available, guidelines recommending standardized pain assessment must be clearly labelled as being based on principles or evidence from other fields of practice, and avoid implying that they are 'evidence based'.
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Manejo da Dor , Medição da Dor/normas , Dor/diagnóstico , Guias de Prática Clínica como Assunto/normas , Criança , Bases de Dados Factuais/estatística & dados numéricos , Humanos , Medição da Dor/métodos , Pediatria , Literatura de Revisão como AssuntoRESUMO
BACKGROUND: Young men who have sex with men (YMSM) in the United States have among the highest incidence of HIV and sexually transmitted infection (STI) and the lowest uptake of HIV and STI testing and pre-exposure prophylaxis (PrEP). Nearly universal mobile phone ownership among youth provides an opportunity to leverage mobile health apps to increase HIV/STI testing and PrEP uptake among YMSM. OBJECTIVE: The goals of this project are to develop and refine LYNX, a novel mobile app to support linkage to HIV/STIs testing and PrEP services among YMSM in the United States, and to evaluate the acceptability and feasibility of LYNX in a pilot randomized controlled trial (RCT). METHODS: This research protocol will be conducted in 3 phases: an iterative development phase with a series of 3 focus groups among 20 YMSM to refine the LYNX app; an open technical pilot among 15 YMSM to optimize usability of the app; and then a 6-month pilot RCT among 60 HIV-uninfected YMSM at risk for HIV acquisition. Developed using the Information, Motivation, and Behavioral skills theoretical model, the LYNX app includes an electronic diary to track sexual behaviors (information), a personalized risk score to promote accurate risk perception (information/motivation), testing reminders (motivation/behavioral skills), and access to home-based HIV/STI testing options and geospatial-based HIV/STI testing care sites (behavioral skills). Feasibility and acceptability will be assessed through app analytics of usage patterns and acceptability scales administered via computer-assisted self-interview at 3 and 6 months. We will also evaluate preliminary efficacy by comparing the proportion of YMSM who test at least once during the 6-month pilot and the proportion who successfully link to a PrEP provider in the intervention versus control groups. RESULTS: Formative work is currently underway. The LYNX pilot RCT will begin enrollment in October 2018, with study results available in 2019. CONCLUSIONS: The LYNX app is one of the first mobile apps designed to increase HIV/STI testing and PrEP uptake among YMSM. As low-perceived risk is a barrier to HIV/STI testing and PrEP use among youth, the personalized risk assessment and interactive sexual diary in LYNX could assist YMSM in better understanding their HIV risk and providing motivation to test for HIV/STIs and initiate PrEP. Coupled with community-based recruitment, this novel mobile app has great potential to reach and engage YMSM not currently involved in care and increase rates of HIV/STI testing and PrEP uptake in this vulnerable population. TRIAL REGISTRATION: ClinicalTrials.gov NCT03177512; https://clinicaltrials.gov/ct2/show/NCT03177512 (Archived by WebCite at http://www.webcitation.org/73c917wAw). INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/10659.
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Chronic pain is a widespread and significant clinical problem. It can result in major negative short- and long-term physical and emotional effects in multiple domains of children's and their families' lives as Pain Associated Disability Syndrome. Assessment of chronic pain is challenging but it is an essential clinical task. Management requires a multidimensional response focussing on the whole patient. Specialist pain management units and programmes use cognitive behavioural methods and promote adaptive coping and focus on the child re-engaging with normal activities. While chronic pain is not well understood, there is emerging evidence that young people and their parents can recover from chronic disability, dependency and distress, and return to a normal life.
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Dor , Adaptação Psicológica , Adolescente , Criança , Doença Crônica , Humanos , Dor/diagnóstico , Dor/enfermagem , Dor/psicologia , Manejo da Dor , Medição da Dor , Psicoterapia/métodosRESUMO
Accurate assessment of pain in children and young people is an essential nursing skill that forms the basis of any pain management intervention. This article outlines the different tools available to assess acute and chronic pain in children and young people. Validity and reliability of these tools is discussed and the importance of factors such as level of cognitive development and age are emphasised.
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Dor Crônica/diagnóstico , Medição da Dor/enfermagem , Pediatria/métodos , Criança , Pré-Escolar , Barreiras de Comunicação , Humanos , Medição da Dor/métodos , Reprodutibilidade dos Testes , Reino UnidoRESUMO
BACKGROUND: Pharmacists by their training have the competences and skills to promote safe use of medicines which is an essential component of patient safety. This study explored the perceptions of hospital pharmacists' role in medication safety in Ghana, identified their attendant challenges and ways of enhancing such roles in the future. METHOD: A self-administered questionnaire was delivered to 200 pharmacists selected conveniently from the 10 regions of Ghana. Questions in the questionnaire were based on a systematic literature review that had catalogued and summarised all the activities of hospital pharmacists related to medication safety. RESULTS: A total of 176 (88% response rate) questionnaires were completed and returned. Almost all pharmacists (97.7%) believed that they were involved in medication safety activities in their daily routine. The frequently performed activities were counselling of out-patient (91.8%), training pharmacy and other clinical students (72.2%), reporting on medication errors (70%), and reconciling medications (69.2%). The mean weekly time spent on the activities ranged from 6.5 to 19.8 hours. Participants who had clinical pharmacy related additional qualifications (χ2 = 37.749; p = 0.049) and worked in tertiary care hospitals (χ2 = 26.6; p = 0.377) undertook more medication safety activities than those without. The cited challenges faced by participants included inadequate time available (62.7%), spending most time in managerial activities (47.3%), lack of formal structures of engagement (43.8%), lack of motivation by superiors (34.9%), and no formal schedule by supervisor (32%). Only 7.7% stated they lack interest in performing those activities. CONCLUSIONS: Pharmacists undertake many medication safety activities routinely that they perceive to have impact on patient care outcomes. Restructuring of their managerial roles will contribute to freeing time for pharmacists to engage more in those activities.
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Segurança do Paciente , Farmacêuticos/organização & administração , Serviço de Farmácia Hospitalar/organização & administração , Gestão da Segurança/organização & administração , Sistemas de Notificação de Reações Adversas a Medicamentos , Estudos Transversais , Feminino , Gana , Humanos , Relações Interprofissionais , Masculino , Erros de Medicação/prevenção & controle , Reconciliação de Medicamentos/organização & administração , Conduta do Tratamento Medicamentoso/organização & administração , Papel ProfissionalRESUMO
BACKGROUND: Given the elevated potential for primary or transmitted drug resistance (TDR) among newly HIV-infected individuals, there is a need for a deeper understanding of the baseline resistance patterns present in young men of color who have sex with men. METHODS: Genotypic data were collected for participants aged 13-24 who were enrolled from seven sites. Univariate and bivariate methods were used to describe the prevalence of TDR and characteristics associated with TDR. RESULTS: Of the 296 individuals participating in the substudy, 145 (49%) had baseline genotypes. The majority of the individuals were African American (65%) and gay-identified (70%). There was significant variation in genotype availability by site (p < .001). Major surveillance drug resistance mutations were present in 28 subjects (19.3%); the majority were non-nucleoside reverse transcriptase inhibitor mutations (12.4%). Subjects with TDR were less likely to have used alcohol on 1 or more days in the prior 2 weeks. Location was not associated with acquisition of TDR. CONCLUSIONS: There was a high rate of TDR in a geographically and racially diverse sample of HIV-infected young men of color who have sex with men. This represents a serious public health concern given the young age of this sample and the potential need for long-term antiretroviral therapy. These findings underscore the critical roles of both early case identification and secondary prevention.
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Farmacorresistência Viral/genética , Genes pol/genética , Infecções por HIV/etnologia , Infecções por HIV/genética , HIV-1/genética , Homossexualidade Masculina/etnologia , Homossexualidade Masculina/genética , Antirretrovirais/uso terapêutico , Estudos de Coortes , Genótipo , Infecções por HIV/transmissão , Infecções por HIV/virologia , HIV-1/efeitos dos fármacos , Humanos , Masculino , Prevalência , Inibidores da Transcriptase Reversa/uso terapêutico , Infecções Sexualmente Transmissíveis/etnologia , Infecções Sexualmente Transmissíveis/genética , Estados Unidos/epidemiologia , Adulto JovemAssuntos
Parto Domiciliar/métodos , Segunda Fase do Trabalho de Parto/fisiologia , Lacerações/prevenção & controle , Tocologia/métodos , Períneo/lesões , Anestesia Epidural/efeitos adversos , Episiotomia/efeitos adversos , Terapia por Exercício/métodos , Feminino , Parto Domiciliar/psicologia , Humanos , Segunda Fase do Trabalho de Parto/psicologia , Lacerações/etiologia , Massagem/métodos , Estado Nutricional , Períneo/fisiologia , Postura , Gravidez , Fatores de RiscoRESUMO
Although many studies have shown that stronger ethnic identity is associated with better adjustment, the role of ethnic identity in the context of race-related threat is unclear. The purpose of this study was to examine the effect of ethnic identity on the severity of posttraumatic stress disorder (PTSD) symptoms in the context of race-related stress, particularly to examine whether ethnic identity moderates the effect of racism on consequent PTSD symptoms. Subjects were 91 undergraduate students (11% Caucasian, 6.6% African American, 18.7% Hispanic, 47.3% Asian, 5.5% Middle Eastern, and 8.8% Other) who reported experiences of race-related stress. Race-related stress, ethnic identity, and PTSD symptoms were assessed through self-report measures. Results of a simultaneous multiple regression indicated that ethnic identity moderated PTSD symptoms in response to perceived racism, such that stronger ethnic identity was associated with more PTSD symptoms in the face of increasing levels of race-related stress. Additionally, race-related stress independently predicted PTSD symptoms. These results are consistent with previous findings that ethnic identity increases the experience of distress in the context of self-relevant threat.
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Preconceito , Classe Social , Transtornos de Estresse Pós-Traumáticos/psicologia , Estudantes/psicologia , Adaptação Psicológica , Adulto , Feminino , Humanos , Masculino , Inquéritos e QuestionáriosRESUMO
BACKGROUND: Morphine is commonly used for chest drain removal pain, although a few studies in adults suggest that inhalation agents may be effective for this procedure. Little is known about chest drain removal pain and its management in children. METHODS: Three separate studies were carried out at a large tertiary pediatric hospital to examine the characteristics and management of chest drain removal pain in children. Study 1 examined the prevalence and clinical characteristics of pain and analgesic practices in 135 nonventilated children aged 1 week to 18 years having chest drains removed. Study 2 was an observation study to determine the efficacy and safety of self-administered Entonox (50% nitrous oxide and oxygen) for chest drain removal pain in 30 children aged 7-18 years. Study 3 was a pilot randomized controlled trial comparing intravenous morphine and continuous flow Entonox for chest drain removal pain in 14 children aged 3.5 months to 2.75 years. RESULTS: In study 1, the prevalence of moderate to severe pain during chest drain removal was 76%. Morphine was commonly given preprocedure, but the dose varied considerably. In study 2, children experienced a significant increase in pain during the procedure compared with preprocedure pain at rest, despite receiving Entonox, morphine and/or diclofenac. However, procedure pain was no worse than preprocedure pain during movement or deep breathing. A few minor side effects occurred, which resolved spontaneously. In study 3, no differences were found in pain between the two treatment groups. Children experienced moderate to severe pain during the procedure, despite receiving Entonox or morphine. CONCLUSIONS: Morphine or Entonox alone are unlikely to provide adequate analgesia for chest drain removal pain in children. More research is needed to determine the most effective interventions for this procedure.
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Analgésicos não Narcóticos , Analgésicos Opioides , Tubos Torácicos , Remoção de Dispositivo/efeitos adversos , Drenagem/instrumentação , Morfina , Óxido Nitroso , Oxigênio , Dor/prevenção & controle , Adolescente , Analgesia Controlada pelo Paciente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Dor/etiologia , Medição da DorRESUMO
AIMS AND OBJECTIVES: The purpose of this review was to analyse critically the published research on chest drain removal pain and its management. The findings of descriptive and non-pharmacological intervention studies were summarized and studies of analgesic efficacy were critiqued in depth. BACKGROUND: The removal of a chest drain is a painful and frightening experience, particularly for children. However, there is limited research regarding the amount of pain experienced or effectiveness of analgesia for this procedure. RESULTS: Fourteen studies were reviewed, including five descriptive studies; three studies of non-pharmacological interventions; and six randomized controlled trials of morphine, local anaesthetics and Entonox. The search revealed only two paediatric studies. Many of the studies had design limitations or were poorly reported. The majority of studies indicated that patients experienced moderate to severe pain during chest drain removal, even when morphine or local anaesthetics were given. CONCLUSIONS: Morphine alone does not provide satisfactory analgesia for chest drain removal pain. Non-steroidal anti-inflammatory drugs, local anaesthetics and inhalation agents may have a role to play in providing more effective analgesia for this procedure. RELEVANCE TO CLINICAL PRACTICE: Analgesic protocols for the management of painful procedures such as chest drain removal are unsatisfactory and practice in this area should be revised. More research is needed to determine the efficacy of drugs other than morphine, particularly Entonox and to investigate multi-modal techniques of management further.