Detalhe da pesquisa
1.
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J Chem Inf Model
; 63(9): 2828-2841, 2023 05 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37060320
2.
Identification of sequence motifs in Lhcx proteins that confer qE-based photoprotection in the diatom Phaeodactylum tricornutum.
Plant J
; 108(6): 1721-1734, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34651379
3.
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Mol Hum Reprod
; 27(9)2021 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34463764
4.
Metabolic changes in mouse sperm during capacitation.
Biol Reprod
; 103(4): 791-801, 2020 10 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32614044
5.
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration.
Biol Reprod
; 103(2): 176-182, 2020 08 04.
Artigo
Inglês
| MEDLINE | ID: mdl-32307523
6.
Capacitation increases glucose consumption in murine sperm.
Mol Reprod Dev
; 87(10): 1037-1047, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32914502
7.
Distinct intracellular sAC-cAMP domains regulate ER Ca2+ signaling and OXPHOS function.
J Cell Sci
; 130(21): 3713-3727, 2017 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28864766
8.
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
J Chem Inf Model
; 64(3): 1106, 2024 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38258980
9.
Physiological roles of acid-base sensors.
Annu Rev Physiol
; 77: 347-62, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25340964
10.
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.
Nat Chem Biol
; 12(10): 838-44, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27547922
11.
Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.
J Biol Chem
; 291(18): 9776-84, 2016 Apr 29.
Artigo
Inglês
| MEDLINE | ID: mdl-26961873
12.
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.
Proc Natl Acad Sci U S A
; 111(10): 3727-32, 2014 Mar 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24567411
13.
Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.
J Neurosci
; 34(28): 9281-9, 2014 Jul 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25009261
14.
A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.
FASEB J
; 28(10): 4369-80, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25002117
15.
A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.
Am J Respir Cell Mol Biol
; 51(6): 750-60, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24874272
16.
Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.
J Biol Chem
; 288(49): 35307-20, 2013 Dec 06.
Artigo
Inglês
| MEDLINE | ID: mdl-24129574
17.
CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.
J Biol Chem
; 288(46): 33283-91, 2013 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24100033
18.
cAMP and mitochondria.
Physiology (Bethesda)
; 28(3): 199-209, 2013 May.
Artigo
Inglês
| MEDLINE | ID: mdl-23636265
19.
The uniqueness of on-demand male contraception.
Mol Aspects Med
; 97: 101281, 2024 May 27.
Artigo
Inglês
| MEDLINE | ID: mdl-38805792
20.
Pharmacological distinction between soluble and transmembrane adenylyl cyclases.
J Pharmacol Exp Ther
; 347(3): 589-98, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24091307