RESUMO
Each year, drugs must be withdrawn from the market following the identification of serious adverse reactions. We report here on an enquiry addressed to persons involved in the recent withdrawal of nefazodone, and a survey of physicians and pharmacists. Our results show the complexities of such withdrawal decisions and the difficulty in communicating them through the network of health professionals down to the patients.
Assuntos
Sistemas de Notificação de Reações Adversas a Medicamentos/legislação & jurisprudência , Antidepressivos de Segunda Geração/toxicidade , Indústria Farmacêutica/legislação & jurisprudência , Serviços de Informação sobre Medicamentos/legislação & jurisprudência , Triazóis/toxicidade , Atitude do Pessoal de Saúde , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Comunicação , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Humanos , Relações Interprofissionais , Piperazinas , SuíçaRESUMO
Adverse drug reactions represent a partly preventable cause of morbidity. Computer-based tools may be useful for the prevention of those events resulting from drug interactions. While several such tools are currently available to practitioners, they have rarely been compared regarding their performances and limits. This article presents a benchmark evaluation of seven drug interaction databases which may be elected by physicians or pharmacists as an aid to prescription on a regular basis. None of the databases tested appears to be perfect, and the systems vary in their overall completeness and ease of use.