Detalhe da pesquisa
1.
Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11ß hydroxysteroid dehydrogenase type 1 inhibitor.
Bioorg Med Chem
; 25(14): 3649-3657, 2017 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28528082
2.
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Bioorg Med Chem Lett
; 26(20): 5044-5050, 2016 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27599745
3.
Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.
Bioorg Med Chem
; 24(6): 1384-91, 2016 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26897089
4.
Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.
Mol Pharmacol
; 82(4): 719-27, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22810003
5.
Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.
Bioorg Med Chem Lett
; 21(16): 4836-43, 2011 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21741239
6.
Discovery and optimization of adamantyl carbamate inhibitors of 11ß-HSD1.
Bioorg Med Chem Lett
; 20(22): 6725-9, 2010 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20864344
7.
Spirocyclic ureas: orally bioavailable 11 beta-HSD1 inhibitors identified by computer-aided drug design.
Bioorg Med Chem Lett
; 20(3): 881-6, 2010 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20064717
8.
Optimization of orally bioavailable alkyl amine renin inhibitors.
Bioorg Med Chem Lett
; 20(2): 694-9, 2010 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19959358
9.
Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
Bioorg Med Chem Lett
; 19(13): 3541-5, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19457666
10.
Purification and characterization of recombinant human renin for X-ray crystallization studies.
BMC Biochem
; 9: 19, 2008 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-18582379
11.
Cloning, characterization and site-directed mutagenesis of canine renin.
J Biochem
; 142(6): 671-80, 2007 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-17942478
12.
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) ß Agonist.
J Med Chem
; 59(7): 3264-71, 2016 Apr 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26990539
13.
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
ACS Med Chem Lett
; 2(10): 747-51, 2011 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24900262
14.
Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11ß-hydroxysteroid dehydrogenase type 1.
J Med Chem
; 54(17): 6050-62, 2011 Sep 08.
Artigo
Inglês
| MEDLINE | ID: mdl-21786805