Detalhe da pesquisa
1.
NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.
Am J Physiol Gastrointest Liver Physiol
; 326(5): G543-G554, 2024 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38252683
2.
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.
Cell
; 135(1): 49-60, 2008 Oct 03.
Artigo
Inglês
| MEDLINE | ID: mdl-18854154
3.
Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.
Am J Physiol Gastrointest Liver Physiol
; 316(3): G412-G424, 2019 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30605011
4.
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Proc Natl Acad Sci U S A
; 105(26): 9059-64, 2008 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18579783
5.
Identification and characterization of a small molecule antagonist of human VPAC(2) receptor.
Mol Pharmacol
; 77(1): 95-101, 2010 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19854890
6.
Human Cep192 is required for mitotic centrosome and spindle assembly.
Curr Biol
; 17(22): 1960-6, 2007 Nov 20.
Artigo
Inglês
| MEDLINE | ID: mdl-17980596
7.
An intracellular conformational sensor assay for Abl T315I.
Anal Biochem
; 385(2): 300-8, 2009 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19059193
8.
A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity.
Anal Biochem
; 390(1): 85-7, 2009 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19328766
9.
Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.
Anal Biochem
; 392(2): 162-8, 2009 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19482004
10.
Cancer cell-based genomic and small molecule screens.
Adv Cancer Res
; 96: 145-73, 2007.
Artigo
Inglês
| MEDLINE | ID: mdl-17161679
11.
Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice.
J Cardiovasc Pharmacol Ther
; 23(3): 244-253, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29130735
12.
Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).
J Med Chem
; 61(17): 7589-7613, 2018 09 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30141927
13.
Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
Sci Transl Med
; 10(456)2018 08 29.
Artigo
Inglês
| MEDLINE | ID: mdl-30158152
14.
Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus.
Mol Cell Biol
; 23(3): 831-41, 2003 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-12529389
15.
Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform.
Stem Cell Reports
; 9(6): 1976-1990, 2017 12 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29153987
16.
Ontology recapitulates physiology.
Chem Biol
; 10(9): 784-6, 2003 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-14522048
17.
Fulfilling the promise: drug discovery in the post-genomic era.
Drug Discov Today
; 8(4): 168-74, 2003 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-12581711
18.
Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.
J Clin Endocrinol Metab
; 88(10): 4990-6, 2003 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-14557485
19.
An interview with Jeremy S. Caldwell.
Assay Drug Dev Technol
; 6(3): 299-306, 2008 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-18593374
20.
Parsimonious discovery of synergistic drug combinations.
ACS Chem Biol
; 6(12): 1391-8, 2011 Dec 16.
Artigo
Inglês
| MEDLINE | ID: mdl-21974780