Detalhe da pesquisa
1.
Tuning Hsp104 specificity to selectively detoxify α-synuclein.
Mol Cell
; 83(18): 3314-3332.e9, 2023 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-37625404
2.
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.
Cell
; 156(1-2): 170-82, 2014 Jan 16.
Artigo
Inglês
| MEDLINE | ID: mdl-24439375
3.
Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models.
Proc Natl Acad Sci U S A
; 120(7): e2210712120, 2023 02 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36745808
4.
Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans.
PLoS Genet
; 18(8): e1010115, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35984862
5.
From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models.
Hum Mol Genet
; 31(R1): R37-R46, 2022 10 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35994032
6.
A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6.
Proc Natl Acad Sci U S A
; 118(12)2021 03 23.
Artigo
Inglês
| MEDLINE | ID: mdl-33723042
7.
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.
Hum Mol Genet
; 27(24): 4176-4193, 2018 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30508205
8.
Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.
Hum Mol Genet
; 27(9): 1514-1532, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29452354
9.
NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.
Hum Mol Genet
; 26(19): 3823-3836, 2017 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28934392
10.
Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration.
Int J Mol Sci
; 20(13)2019 Jun 29.
Artigo
Inglês
| MEDLINE | ID: mdl-31261893
11.
Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.
J Neurosci
; 37(46): 11085-11100, 2017 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29030433
12.
Clioquinol promotes the degradation of metal-dependent amyloid-ß (Aß) oligomers to restore endocytosis and ameliorate Aß toxicity.
Proc Natl Acad Sci U S A
; 111(11): 4013-8, 2014 Mar 18.
Artigo
Inglês
| MEDLINE | ID: mdl-24591589
13.
Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.
Proc Natl Acad Sci U S A
; 111(38): E3976-85, 2014 Sep 23.
Artigo
Inglês
| MEDLINE | ID: mdl-25201965
14.
Calcineurin determines toxic versus beneficial responses to α-synuclein.
Proc Natl Acad Sci U S A
; 111(34): E3544-52, 2014 Aug 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25122673
15.
RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.
J Neurosci
; 34(48): 16076-85, 2014 Nov 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25429148
16.
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.
Hum Mol Genet
; 21(17): 3785-94, 2012 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22645275
17.
Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.
J Neurosci
; 32(6): 2142-53, 2012 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-22323726
18.
Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.
J Biol Chem
; 287(6): 4107-20, 2012 Feb 03.
Artigo
Inglês
| MEDLINE | ID: mdl-22147697
19.
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
Hum Mol Genet
; 20(20): 3933-42, 2011 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21768216
20.
Lysosomal impairment in Parkinson's disease.
Mov Disord
; 28(6): 725-32, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23580333