RESUMO
In the present paper, we report the case of a patient with long-standing Crohn s disease and multiple complications that, after receiving treatment with infliximab, was diagnosed with an adenocarcinoma of the rectum and anus that required radical surgery, later presenting multiple metastases. In the discussion, characteristics and major risk factors for colorectal cancer in patients with inflammatory bowel disease will be largely reviewed, and current studies will be analyzed in connection with the appearance of neoplasms in patients being treated with biologics.
Assuntos
Adenocarcinoma/induzido quimicamente , Anticorpos Monoclonais/efeitos adversos , Neoplasias do Ânus/induzido quimicamente , Doença de Crohn/tratamento farmacológico , Neoplasias Retais/induzido quimicamente , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Anticorpos Monoclonais/uso terapêutico , Humanos , Infliximab , Masculino , Pessoa de Meia-IdadeRESUMO
Hypercalcemia due to hyperparathyroidism is a rare etiology for acute pancreatitis, oscillating between 1.5 and 7% in the different series. Although the cause-effect relationship and the pathophysiology of the condition are not clear, it seems that the association among them is not incidental, and serum calcium could be a major risk factor, so that pancreatitis would come to occur during severe hypercalcemia attacks. Mutations in different genes have been proposed as well to justify why only some patients with primary hyperparathyroidism and hypercalcemia develop acute pancreatitis. References to cases like these ones are rare in the literature. We report two patients with acute pancreatitis associated with hyperparathyroidism and hypercalcemia, one of them with a fatal outcome.
Assuntos
Hipercalcemia/complicações , Hiperparatireoidismo/complicações , Pancreatite/etiologia , Doença Aguda , Idoso , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Hepatic angiosarcoma is a rare primary tumor of the liver with a mesenchymal origin. Diagnosis is difficult because clinical manifestations and imaging studies are inconclusive. In many cases a diagnosis is obtained during necropsy, not being apparent during the course of disease. It is associated with several risk factors, but these contribute to explaining only a few of all reported cases. When clinical manifestations begin progression is often fast, and possibilities for curative treatment are limited.We report two cases of hepatic angiosarcoma. In the first one, our patient had an insidious initial course, and then suddenly presented with hepatic failure followed by acute respiratory distress. A diagnosis was reached during necropsy. In the second case, we initiated the study of a chronic liver disease using fine-needle aspiration biopsy, which showed findings suggestive of hepatic angiosarcoma. In the following weeks the patient started on a torpid clinic course, and died from multiple organ failure.
Assuntos
Hemangiossarcoma , Neoplasias Hepáticas , Idoso , Evolução Fatal , Hemangiossarcoma/diagnóstico , Humanos , Neoplasias Hepáticas/diagnóstico , MasculinoRESUMO
AIM: Colonoscopy has become accepted as the most effective method for colon exploration. Some application problems have been detected in the setting of normal clinical care due to its wide range of uses in recent years, and therefore there is a need to measure colonoscopy quality. For that purpose valid quality indicators are necessary to be defined. The application process of some quality indicators is presented in this study. The proposed indicators in this study are: quality of bowel preparation, cecal intubation rate, withdrawal time, adenoma detection rate, and adenoma removal rate. MATERIAL AND METHOD: This is a prospective 12-month study where colonoscopies performed in the VI health area of Murcia Region were evaluated. From February 2006 to February 2007 a total of 609 subjects were eligible for colonoscopy after a positive fecal blood test in the setting of a colorectal cancer screening program. A sample of thirty patients (n: 30) was considered representative to assess the reliability of quality indicators and for a preliminary analysis of results. RESULTS: Indicators results are: quality of bowel preparation (87%), kappa 0.74 (95% CI: 0.48-0.99); cecal intubation rate (90%) 0.74 (95% CI: 0.49-0.99); adenoma detection and removal rate (96%), kappa: 0.78 (95% CI: 0.53-0.99); withdrawal time: 13.36 min (95% CI: 10.48-16.11). Kappa: 0.78 (95% CI: 0.49-0.99). CONCLUSIONS: Quality indicators definition and application in colonoscopy performance is possible. More studies are necessary to define the role of these indicators in the setting of clinical practice.
Assuntos
Colonoscopia/normas , Catárticos , Ceco , Pólipos do Colo/patologia , Pólipos do Colo/cirurgia , Colonoscopia/métodos , Neoplasias Colorretais/diagnóstico , Sedação Consciente , Humanos , Hiperplasia , Programas de Rastreamento , Sangue Oculto , Cuidados Pré-Operatórios , Estudos Prospectivos , Garantia da Qualidade dos Cuidados de Saúde , Indicadores de Qualidade em Assistência à Saúde , Espanha , Fatores de TempoRESUMO
Budd-Chiari syndrome can be defined as an interruption or diminution of the normal blood flow out of the liver. Patients with Budd-Chiari syndrome present with varying degrees of symptomatology that can be divided into the following categories: fulminant, acute, subacute and chronic. The subacute form is the most common presentation. A majority of patients with Budd-Chiari syndrome have an underlying hypercoagulability state. We present the case of a young woman with Crohn s disease on oral contraceptives who developed bilateral pulmonary thromboembolism and Budd-Chiari syndrome.
Assuntos
Síndrome de Budd-Chiari/complicações , Anticoncepcionais Orais/efeitos adversos , Doença de Crohn/complicações , Etinilestradiol/efeitos adversos , Embolia Pulmonar/induzido quimicamente , Adulto , Síndrome de Budd-Chiari/diagnóstico por imagem , Colonoscopia , Doença de Crohn/diagnóstico , Doença de Crohn/diagnóstico por imagem , Feminino , Heparina de Baixo Peso Molecular/uso terapêutico , Humanos , Embolia Pulmonar/diagnóstico por imagem , Embolia Pulmonar/tratamento farmacológico , Radiografia Abdominal , Radiografia Torácica , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Hepatic hemangioma is the most frequent liver's tumor. The majority are small, asymptomatic and have an excellent prognosis. Those larger than 5 cm can be associated to a consumptive coagulopathy called Kasabach-Merrit syndrome. We present a patient with a giant hepatic hemangioma with multiple hemangimatosis associated to Kasabach-Merrit syndrome.
Assuntos
Coagulação Intravascular Disseminada/complicações , Hemangioma/complicações , Neoplasias Hepáticas/complicações , Adulto , Hemangioma/patologia , Humanos , Neoplasias Hepáticas/patologia , MasculinoAssuntos
Lesões por Radiação/patologia , Doenças Retais/patologia , Adenocarcinoma/complicações , Adenocarcinoma/radioterapia , Idoso , Colonoscopia , Endoscopia , Humanos , Masculino , Neoplasias da Próstata/complicações , Neoplasias da Próstata/radioterapia , Lesões por Radiação/etiologia , Lesões por Radiação/terapia , Doenças Retais/etiologia , Doenças Retais/terapiaRESUMO
OBJECTIVE: To study the clinical course of patients with a serum monoclonal protein at Guadalajara Health Area. MATERIAL AND METHODS: Prospective study of 186 patients with a newly diagnosed monoclonal component. They have been collected during the years 1999 and 2000. RESULTS: The cumulative transformation probability at 43 months was 4.99% for those patients whose monoclonal gammopathy was overlooked, and 2% at 23 months for patients with monoclonal gammopathy of undetermined significance. The cumulative probability of survival for patients with multiple myeloma was 66.7% at 21 months. The conditional mortality rate (patients/months) at 4 years due to haematological disease was 4.48 x 10(-4) for overlooked patients, 0 for diagnosed of monoclonal gammopathy of undetermined significance and 1.388 x 10(-2) for multiple myeloma diagnosed. DISCUSSION: A non malignant M component must be followed up due to it could increase patients survival rate in relation with transformation in malignant disease.
Assuntos
Paraproteinemias/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , EspanhaAssuntos
Neoplasias Pancreáticas/patologia , Neoplasias Pancreáticas/cirurgia , Papiloma Intraductal/patologia , Papiloma Intraductal/cirurgia , Humanos , Neoplasias Pancreáticas/mortalidade , Pancreaticoduodenectomia , Papiloma Intraductal/mortalidade , Estudos Retrospectivos , Resultado do TratamentoAssuntos
Neoplasias Duodenais/complicações , Neoplasias Duodenais/secundário , Hemorragia Gastrointestinal/etiologia , Mesotelioma/complicações , Mesotelioma/secundário , Neoplasias Pleurais/patologia , Neoplasias Duodenais/diagnóstico por imagem , Duodeno/patologia , Dispneia/etiologia , Hemorragia Gastrointestinal/diagnóstico por imagem , Humanos , Masculino , Mesotelioma/diagnóstico por imagem , Pessoa de Meia-Idade , Neoplasias Pleurais/diagnóstico por imagem , Radiografia , Fumar/patologiaAssuntos
Dor Abdominal/etiologia , Corpos Estranhos/complicações , Estômago , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
The immunosuppressive drug cyclosporine A (CsA) has been successfully used in several diseases with immunological basis and in transplant patients. Nephrotoxicity is the main secondary effect of CsA treatment. Although the mechanisms of nephrotoxitity are not completely defined, there is evidence that suggests the role of reactive oxygen species (ROS) in its pathogenesis. It has been demonstrated in numerous in vivo and in vitro experiments that CsA induced renal failure and increased the synthesis of ROS, thromboxane (TX) and lipid peroxidation products in the kidney. Furthermore, CsA modified the expression and activity of several renal enzymes (ciclooxygenase, superoxide-dismutase, catalase and glutathione-peroxidase). Antioxidant nutrients (e.g. Vitamins E and C) can neutralize some of the effects that CsA produced in the kidney. Thus, Vit E inhibited the synthesis of ROS and TX and the lipid peroxidation process induced by CsA in kidney structures. Antioxidants can also improve renal function and histological damage produced by CsA administration. Although there are few data in humans treated with CsA, the possibility exists that antioxidants can also neutralize CsA nephrotoxicity and LDL oxidation. Thus, antioxidant nutrients could have a therapeutic role in transplant patients treated with CsA.