"Unplugged," a European school-based program for substance use prevention among adolescents: overview of results from the EU-Dap trial.

The EU-Dap study aimed to develop and evaluate a school-based curriculum for the prevention of substance use among young people. The school curriculum, "Unplugged," is based on social influence approach and addresses social and personal skills, knowledge, and normative beliefs. It consists of 12 one-hour interactive sessions delivered by teachers. Its effectiveness was evaluated through a randomized trial involving 7,079 pupils of seven European countries. Unplugged was effective in reducing cigarette smoking, episodes of drunkenness, and the use of cannabis at short term. This association, however, was confined to boys, with age and self-esteem as possible explanations of this difference. Beneficial effects associated with the program persisted at fifteen-month follow-up for drunkenness, alcohol-related problems, and cannabis use, and were stronger among adolescents in schools of average low socioeconomic level. These results are of scientific importance and may inform the adoption of effective public health interventions at population level.

Classroom characteristics and implementation of a substance use prevention curriculum in European countries.

BACKGROUND: Partial implementation may explain modest effectiveness of many school-based preventive programmes against substance use. We studied whether specific characteristics of the class could predict the level of implementation of a curriculum delivered by class teachers in schools from some European countries. METHODS: Secondary analysis of data from an evaluation trial. In seven European countries, 78 schools (173 classes) were randomly assigned to a 12-unit, interactive, standardized programme based on the comprehensive social influence model. Curriculum completeness, application fidelity, average unit duration and use of role-play were monitored using structured report forms. Predictors of implementation were measured by aggregating at class level information from the baseline student survey. Class size, gender composition, mean age, factors related to substance use and to affection to school were analysed, with associations estimated by multilevel regression models. RESULTS: Implementation was not significantly predicted by mean age, proportion of students with positive academic expectation or liking school. Proportion of boys was associated with a shorter time devoted to each unit [ß = -0.19, 95% confidence intervals (CI) -0.32 to -0.06]. Class size was inversely related to application fidelity [Odds ratio (OR) 0.92, 95% CI 0.85 to 0.99]. Prevalence of substance use was associated with a decreased odds of implementing all the curriculum units (OR 0.81, 95% CI 0.65 to 0.99). Students' connectedness to their class was associated with increased odds of teachers using role-play (OR 1.52, 95% CI 1.03 to 2.29). CONCLUSIONS: Teachers' implementation of preventive programmes may be affected by structural and social characteristics of classes and therefore benefit from organizational strategies and teachers' training in class management techniques.

The effect of Teflon coating on the resistance to sliding of orthodontic archwires.

Teflon is an anti-adherent and aesthetic material. The aim of this study was to evaluate, in vitro, the influence of Teflon coating on the resistance to sliding (RS) of orthodontic archwires. For this purpose, Teflon-coated archwires were examined using frictional resistance tests by means of a universal testing machine and compared with conventional uncoated wires. Twelve types of archwires with round and rectangular sections (0.014, 0.018, and 0.018 × 0.025 inches) and of different materials (stainless steel and nickel-titanium) were tested with two passive self-ligating brackets (SmartClip™ and Opal(®)) and one active self-ligating bracket (Quick(®)). Each archwire-bracket combination was tested 10 times under 8 simulated clinical scenarios. Statistical comparisons were conducted between the uncoated and Teflon-coated archwires using Wilcoxon and Mann-Whitney tests, and linear regression analysis. For all bracket-archwire combinations, Teflon-coated archwires resulted lower friction than the corresponding uncoated archwires (P < 0.01). The results showed that Teflon coating has the potential to reduce RS of orthodontic archwires.

The influence of socioeconomic environment on the effectiveness of alcohol prevention among European students: a cluster randomized controlled trial.

BACKGROUND: Although social environments may influence alcohol-related behaviours in youth, the relationship between neighbourhood socioeconomic context and effectiveness of school-based prevention against underage drinking has been insufficiently investigated. We study whether the social environment affects the impact of a new school-based prevention programme on alcohol use among European students. METHODS: During the school year 2004-2005, 7079 students 12-14 years of age from 143 schools in nine European centres participated in this cluster randomised controlled trial. Schools were randomly assigned to either control or a 12-session standardised curriculum based on the comprehensive social influence model. Randomisation was blocked within socioeconomic levels of the school environment. Alcohol use and alcohol-related problem behaviours were investigated through a self-completed anonymous questionnaire at baseline and 18 months thereafter. Data were analysed using multilevel models, separately by socioeconomic level. RESULTS: At baseline, adolescents in schools of low socioeconomic level were more likely to report problem drinking than other students. Participation in the programme was associated in this group with a decreased odds of reporting episodes of drunkenness (OR = 0.60, 95% CI = 0.44-0.83), intention to get drunk (OR = 0.60, 95% CI = 0.45-0.79), and marginally alcohol-related problem behaviours (OR = 0.70, 95% CI = 0.46-1.06). No significant programme's effects emerged for students in schools of medium or high socioeconomic level. Effects on frequency of alcohol consumption were also stronger among students in disadvantaged schools, although the estimates did not attain statistical significance in any subgroup. CONCLUSIONS: It is plausible that comprehensive social influence programmes have a more favourable effect on problematic drinking among students in underprivileged social environments. TRIAL REGISTRATION: ISRCTN: ISRCTN18092805.

The impact of different sources of body mass index assessment on smoking onset: An application of multiple-source information models.

Multiple-source data are often collected to provide better information of some underlying construct that is difficult to measure or likely to be missing. In this article, we describe regression-based methods for analyzing multiple-source data in Stata. We use data from the BROMS Cohort Study, a cohort of Swedish adolescents who collected data on body mass index that was self-reported and that was measured by nurses. We draw together into a single frame of reference both source reports and relate these to smoking onset. This unified method has two advantages over traditional approaches: 1) the relative predictiveness of each source can be assessed and 2) all subjects contribute to the analysis. The methods are applicable to other areas of epidemiology where multiple-source reports are used.

[Paclitaxel-coated balloons for in-stent restenosis treatment: long-term clinical results and predictors of recurrent target lesion revascularization]. / Palloncini medicati a eluizione di paclitaxel nel trattamento delle ristenosi intrastent: risultati clinici a lungo termine e predittori di nuova rivascolarizzazione della lesione bersaglio.

BACKGROUND: The aim of this study was to report clinical outcomes in patients treated with paclitaxel-coated balloons (PCB) for in-stent restenosis (ISR) in both bare metal (BMS) and drug-eluting stent (DES). METHODS: Between May 2009 and December 2015, we treated 155 ISR in 140 patients. At recruitment, 35% of patients had diabetes. Among the lesions, 125 were first occurrence (55 within BMS and 70 within DES) and 30 recurrent; 24 ISR were multi-metal layered. Mean reference diameter was 2.79 ± 0.52 mm and mean lesion length 13.2 ± 7.1 mm. PCB use included 32 Dior I, 97 InPact Falcon, 18 Panthera Lux, and 8 Restore DEB. RESULTS: At a median follow-up of 442 days, we observed 18 target lesion revascularizations (TLR), one myocardial infarction, 3 cardiac deaths, and 5 non-cardiac deaths. TLR occurrence differed according to type of ISR (4% within BMS, 14% within DES, 28% within recurrent ISR; p<0.05). TLR was associated with PCB type (35% Dior I, 9% InPact Falcon, 0% Panthera Lux and Restore DEB; p<0.05). Multivariable analysis revealed that first-generation PCB without a carrier (hazard ratio [HR] 2.50, 95% confidence interval [CI] 0.96-6.50; p=0.06) and recurrent ISR (HR 7.76, 95% CI 1.56-38.66; p=0.01) correlated with subsequent TLR. CONCLUSIONS: Our results confirm the safety and efficacy of PCB for ISR treatment both within BMS and DES. PCB type and recurrent ISR correlate with subsequent TLR.

Periodontal health in teenagers treated with removable aligners and fixed orthodontic appliances.

OBJECTIVES: The purpose of this study was to explore the microbiological and periodontal changes occurring in adolescents during 12 months of orthodontic therapy with removable aligners and with fixed appliances. MATERIAL AND METHODS: During the years 2012-2013, 50 teenagers aged 10-18 years with similar initial orthodontic conditions participated in this trial in a university clinic in northern Italy. After receiving professional oral hygiene and instructions on a standardized oral hygiene protocol, the adolescents were randomly assigned to either orthodontic treatment with traditional fixed brackets (n = 25) or to treatment with Invisalign® aligners (n = 25). Subgingival microbiological samples, probing depth (PD), plaque index (PI), and bleeding on probing (BOP) were obtained and documented from the mesiovestibular subgingival sulcus of the upper right first molar and left central incisor at the beginning of treatment and 3, 6, and 12 months later. Compliance with oral hygiene procedures, full mouth plaque score (FMPS), and full mouth bleeding score (FMBS) were assessed at the beginning of treatment and 12 months later. Two sample independent t-tests and the χ(2) test were used to study whether the indices of periodontal health differed in the teenagers due to the experimental conditions. RESULTS: None of the patients was positive for the periodontal anaerobes analyzed. The PI, PD, BOP, FMPS, and FMBS scores were significantly lower and compliance with oral hygiene was significantly higher in the group treated with Invisalign® than in the group treated with fixed brackets. CONCLUSION: Teenagers treated with removable appliances display better compliance with oral hygiene, less plaque, and fewer gingival inflammatory reactions than their peers with fixed appliances.

Predictors of erroneous perception of being overweight among adolescents.

OBJECTIVE: Adolescents' perception of overweight often disagrees with objective measurements; if factors explaining this discrepancy are potentially modifiable is unclear. METHODS: We analyzed cross-sectional data from a cohort of 2,001 Swedish adolescents (1,026 females, 975 males) at the age of 15 years in 2003. Erroneous perception of overweight was defined as the perception of being overweight in relation to normal or lower than normal BMI (kg/m(2)). BMI measured by the school nurse at 11 years, school-based education on nutrition/physical activity, smoking, alcohol consumption, physical activity, and healthy/unhealthy eating were examined as potential predictors/correlates of overweight misperception in multivariate logistic regression models. RESULTS: At the age of 15 years, 32% of girls and 10% of boys misclassified themselves as overweight. Overweight at 11 years predicted misperception of overweight 4 years later (adjusted odds ratio (OR) = 2.3, 95% confidence interval (95% CI) = 1.4-3.6 in boys; OR = 1.9, 95% CI = 1.3-2.8 in girls). Among girls, smoking was associated with a higher probability of misperception (adjusted OR = 1.6, 95% CI = 1.2-2.2). Among boys, physical activity (>6 h/ week) was associated with a lower probability of misperception (OR = 0.4, 95% CI = 0.2-0.7). No association was observed with school-based education on nutrition and physical activity. CONCLUSION: Preventing overweight in pre-adolescence may be a way to avoid later unjustified weight concerns in adolescence.

Effects of a school-based prevention program on European adolescents' patterns of alcohol use.

PURPOSE: School-based substance abuse prevention programs are widespread but are rarely evaluated in Europe. We aimed to evaluate the effect of a new school-based prevention program against substance use on the frequency of alcohol consumption and alcohol-related problem behaviors among European students. METHODS: During the school year 2004-2005, a total of 7,079 students aged 12-14 years from 143 schools in seven European countries participated in this cluster randomized controlled trial. Schools were randomly assigned to either control (65 schools, 3,532 students) or to a 12-session standardized program based on the comprehensive social influence model (78 schools, 3,547 students). Alcohol use and frequency of alcohol-related problem behaviors were investigated through a self-completed anonymous questionnaire at baseline and 18 months thereafter. The association between intervention and changes in alcohol-related outcomes was expressed as odds ratio (OR), estimated by multilevel regression model. RESULTS: The preventive program was associated with a decreased risk of reporting alcohol-related problems (OR = .78, 95% confidence intervals [CI] = .63-.98), although this reduction was not statistically significant in the subgroup of 743 current drinkers at baseline. The risk for alcohol consumption was not modified by exposure to the program (OR = .93, 95% CI = .79-1.09). In the intervention group, nondrinkers and occasional drinkers at baseline progressed toward frequent drinking less often than in the control group. CONCLUSIONS: School curricula based on the comprehensive social-influence model can delay progression to frequent drinking and reduce occurrence of alcohol-related behavioral problems in European students. These results, albeit moderate, have potentially useful implications at the population level.

Overweight and perception of overweight as predictors of smokeless tobacco use and of cigarette smoking in a cohort of Swedish adolescents.

AIMS: To study the association between measured or perceived overweight in adolescence and subsequent uptake of cigarette smoking and of the Swedish smokeless tobacco 'snus' (oral moist snuff). DESIGN: Population-based prospective cohort study with 7 years' follow-up. SETTING: Self-administered questionnaires and school nurses' visits. PARTICIPANTS: A total of 2922 children of both sexes and mean age 11.6 years at recruitment, resident in the Stockholm region, Sweden. MEASUREMENTS: Tobacco use was self-reported at baseline and on six subsequent surveys. Subjects' height and weight were measured by school nurses during the first 4 years, self-reported thereafter. Overweight perception was self-reported at the age of 15 years. FINDINGS: Overweight and perception of overweight were not associated with subsequent uptake of either smoking or snus among males. Among females, overweight at baseline was associated with uptake of smoking [adjusted hazard ratio (HR) 1.34, 95% confidence interval (CI) 1.09-1.63], but not of snus. A similar pattern was found with overweight status during follow-up. Among girls with low-educated parents, overweight at baseline predicted the uptake of both snus and smoking. Among 15-year-old females who never used tobacco perceived overweight was associated with subsequent uptake of smoking (adjusted HR 1.71, 95% CI 1.20-2.46), but not of snus. CONCLUSIONS: In Sweden, adolescent girls with actual or perceived overweight are at increased risk to start smoking, while indications that this increased risk applies to smokeless tobacco (snus) are limited to girls of low socio-economic status.