Detalhe da pesquisa
1.
NCOA4 transcriptional coactivator inhibits activation of DNA replication origins.
Mol Cell
; 55(1): 123-37, 2014 Jul 03.
Artigo
Inglês
| MEDLINE | ID: mdl-24910095
2.
NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.
Haematologica
; 106(3): 795-805, 2021 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32107334
3.
Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology.
Angew Chem Int Ed Engl
; 54(30): 8717-21, 2015 Jul 20.
Artigo
Inglês
| MEDLINE | ID: mdl-26126987
4.
Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.
J Biol Chem
; 288(24): 17481-94, 2013 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-23629654
5.
Tamoxifen erythroid toxicity revealed by studying the role of nuclear receptor co-activator 4 in erythropoiesis.
Haematologica
; 104(8): e383-e384, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31366467
6.
D898_E901 RET Deletion Is Oncogenic, Responds to Selpercatinib, and Treatment Resistance Can Arise Via RET-Independent Mechanisms.
JCO Precis Oncol
; 7: e2300052, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37535881
7.
NCOA4 links iron bioavailability to DNA metabolism.
Cell Rep
; 40(7): 111207, 2022 08 16.
Artigo
Inglês
| MEDLINE | ID: mdl-35977492
8.
Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
J Med Chem
; 65(2): 1536-1551, 2022 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-35081714
9.
Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation.
Eur J Med Chem
; 216: 113265, 2021 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33652352
10.
Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases.
Sci Rep
; 11(1): 16103, 2021 08 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34373541
11.
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ß-thalassemia mouse model.
J Clin Invest
; 131(10)2021 05 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33822774
12.
RET Gene Fusions in Malignancies of the Thyroid and Other Tissues.
Genes (Basel)
; 11(4)2020 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32326537
13.
Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology.
J Med Chem
; 63(9): 4506-4516, 2020 05 14.
Artigo
Inglês
| MEDLINE | ID: mdl-32298114
14.
Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474.
Endocr Relat Cancer
; 16(1): 233-41, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19029224
15.
Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
J Med Chem
; 62(4): 1731-1760, 2019 02 28.
Artigo
Inglês
| MEDLINE | ID: mdl-30188734
16.
Association between DNA methylation profile and malignancy in follicular-patterned thyroid neoplasms.
Endocr Relat Cancer
; 26(4): 451-462, 2019 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30753136
17.
Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition.
Front Immunol
; 10: 224, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30873154
18.
New therapeutic approaches to treat medullary thyroid carcinoma.
Nat Clin Pract Endocrinol Metab
; 4(1): 22-32, 2008 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-18084343
19.
Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants.
Clin Cancer Res
; 13(11): 3363-9, 2007 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17545544
20.
The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.
Cancer Res
; 66(12): 6280-7, 2006 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16778204