Association Between Acquired Punctal Stenosis and Ocular Surface Disease: the Egg and the Chicken Story.

PURPOSE: This study explores the relationship between acquired punctal stenosis (PS) and ocular surface disease (OSD), assessing causal mechanisms and clinical impacts, utilizing a combination of a comprehensive literature review and a detailed analysis of a patient cohort from a tertiary care center. METHODS: Data from 213 PS patients at Sheba Medical Center were retrospectively analyzed, evaluating various OSD symptoms and treatment effectiveness through standardized clinical assessments and statistical tests. RESULTS: Predominantly older and female, many patients exhibited bilateral PS. OSD symptoms were found in 35.2% of all patients. Treatments like punctoplasty with stents significantly alleviated symptoms. Significant associations between treatment modalities and symptom improvement were identified. CONCLUSIONS: PS and OSD have acomplex, bidirectional relationship that complicates treatment outcomes. This study underscores the need for thorough diagnostic approaches and personalized treatments to improve PS management. Further research is essential to deepen understanding of PS-OSD interactions and develop effective therapies.

The Impact of a Positive Biofire® FilmArray® Gastrointestinal Panel Result on Clinical Management and Outcomes.

The gold standard diagnostic method for gastrointestinal infections is stool culture, which has limited sensitivity and long turnaround time. Infection diagnosis recently shifted to syndrome-based panel assays. This study employed the FilmArray® Gastrointestinal Panel, which detects 22 pathogens simultaneously, to investigate gastrointestinal infection and pathogen distribution in 91 stool samples of patients hospitalized at the Tzafon Medical Center, Israel, during 2020, and to compare the clinical and demographic data of negative vs. positive samples. Among the 61 positive samples (67%), the most common pathogen was Campylobacter (34.4%). Positive test results were associated with a slightly younger patient age (p = 0.012), significantly higher post-diagnosis use of antibiotics (63.9% vs. 36.7%; p = 0.014), and shorter length of stay and time to discharge (p = 0.035, p = 0.003, respectively) than negative test results. To conclude, the FilmArray® Gastrointestinal Panel enabled the early identification of causative infectious agents and enhanced clinical management and outcomes.

Readiness of Small Energy Markets and Electric Power Grids to Global Health Crises: Lessons From the COVID-19 Pandemic.

In this paper we explore how the COVID-19 pandemic, also known as Coronavirus pandemic, affected the operation of small electric grids, and what can this event teach us on the readiness of such grids in the face of future global health crises. We focus on three major effects: changing patterns of generation and consumption, frequency stability, and the joint impact of low consumption and high share of renewable energy sources. Specifically, we analyze changes in consumption in the Israeli, Estonian, and Finnish grids, and attempt to identify patterns of consumption changes that may be explained by the pandemic. We also analyze changes in voltage and frequency, and show that the low consumption caused significant deviations from the nominal values of both parameters. One main conclusion is that the reduced energy consumption during the pandemic is critical, and has a major effect on the operation of small electric grids. Another conclusion is that since the pandemic pushed the relative share of renewable energy to record highs, this event may help us to better understand the influence of a high share of renewables on small grids, thus offering a glance into a renewable-rich future.