Detalhe da pesquisa
1.
GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model.
Br J Haematol
; 202(1): 173-183, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36960712
2.
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Blood
; 137(5): 661-677, 2021 02 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33197925
3.
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature
; 535(7611): 252-7, 2016 07 14.
Artigo
Inglês
| MEDLINE | ID: mdl-27338790
4.
Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice.
Am J Physiol Heart Circ Physiol
; 321(2): H400-H411, 2021 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34213392
5.
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.
Nature
; 523(7559): 183-188, 2015 Jul 09.
Artigo
Inglês
| MEDLINE | ID: mdl-26131937
6.
p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates.
Proc Natl Acad Sci U S A
; 114(14): 3565-3571, 2017 04 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28320958
7.
Cereblon modulators: Low molecular weight inducers of protein degradation.
Drug Discov Today Technol
; 31: 29-34, 2019 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-31200856
8.
Pomalidomide in combination with dexamethasone results in synergistic anti-tumour responses in pre-clinical models of lenalidomide-resistant multiple myeloma.
Br J Haematol
; 172(6): 889-901, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26914976
9.
Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53.
Blood
; 124(10): 1637-44, 2014 Sep 04.
Artigo
Inglês
| MEDLINE | ID: mdl-24990888
10.
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity.
Br J Haematol
; 164(2): 233-44, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24206017
11.
Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
Bioorg Med Chem Lett
; 22(1): 747-52, 2012 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22137342
12.
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.
Bioorg Med Chem Lett
; 22(3): 1427-32, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22226655
13.
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.
Bioorg Med Chem Lett
; 22(3): 1433-8, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22244937
14.
CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.
J Med Chem
; 64(4): 1835-1843, 2021 02 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33591756
15.
Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005.
J Med Chem
; 64(16): 11886-11903, 2021 08 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34355886
16.
Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma.
J Med Chem
; 63(13): 6648-6676, 2020 07 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32130004
17.
UBE2G1 governs the destruction of cereblon neomorphic substrates.
Elife
; 72018 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-30234487
18.
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J Med Chem
; 61(2): 535-542, 2018 01 25.
Artigo
Inglês
| MEDLINE | ID: mdl-28425720
19.
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization.
Mol Cancer Ther
; 14(6): 1295-305, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25855786
20.
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
J Med Chem
; 58(13): 5323-33, 2015 Jul 09.
Artigo
Inglês
| MEDLINE | ID: mdl-26083478