Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2.

One hundred years after the flu pandemic of 1918, the world faces an outbreak of a new severe acute respiratory syndrome, caused by a novel coronavirus. With a high transmissibility, the pandemic has spread worldwide, creating a scenario of devastation in many countries. By the middle of 2021, about 3% of the world population had been infected and more than 4 million people had died. Different from the H1N1 pandemic, which had a deadly wave and ceased, the new disease is maintained by successive waves, mainly produced by new virus variants and the small number of vaccinated people. In the present work, we create a version of the SIR model using the spatial localization of persons, their movements, and considering social isolation probabilities. We discuss the effects of virus variants, and the role of vaccination rate in the pandemic dynamics. We show that, unless a global vaccination is implemented, we will have continuous waves of infections.

Aqueous chlorination of herbicide metribuzin: Identification and elucidation of "new" disinfection by-products, degradation pathway and toxicity evaluation.

A widely used herbicide, metribuzin, was evaluated for degradation, mineralization and disinfection by-products (DBPs) formation during aqueous chlorination. In addition, to assess the toxicity effects of chlorination on metribuzin solution the following tests were performed: acute toxicity using Artemia salina nauplii; cell viability using MTT assay; estrogenicity using a re-engineered Bioluminescent Yeast Estrogen Screen (BLYES) and a constitutively bioluminescent strain (BLYR); mutagenicity and developmental toxicity using Q(SAR) methodology. Metribuzin at 10 mg·L-1 was degraded by chlorination, achieving 93% of removal at 30 min of reaction. TOC analysis showed that the herbicide does not suffer complete mineralization, even after 24 h of contact with free chlorine. Seventeen DBPs were detected and their structural formulae were elucidated by high resolution mass spectrometry. Toxicity effects for chlorinated solutions increased when compared to the unreacted metribuzin solution. DBPs were more toxic to Artemia salina nauplii, increasing around 20% on nauplii mortality. It was also observed high estrogenicity to human receptors in BLYES assays and mutagenic and developmental toxicant effects to animals and humans in Q(SAR) methodology, suggesting that DBPs are potentially more toxic than the precursor metribuzin. Metribuzin solutions at 10 mg·L-1 showed equivalent 17-ß-estradiol values ranged from 0.061 to 6.71 µg·L-1 after to be chlorinated at different reaction times.