Detalhe da pesquisa
1.
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol Cell
; 83(5): 770-786.e9, 2023 03 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36805027
2.
A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Nucleic Acids Res
; 52(4): 1661-1676, 2024 Feb 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38084912
3.
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Nucleic Acids Res
; 50(6): 3254-3275, 2022 04 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35212371
4.
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
J Am Chem Soc
; 143(44): 18467-18480, 2021 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34648292
5.
Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer.
Med Res Rev
; 40(3): 1061-1083, 2020 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31782213
6.
CITCO Directly Binds to and Activates Human Pregnane X Receptor.
Mol Pharmacol
; 97(3): 180-190, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31882411
7.
Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat Chem Biol
; 13(8): 850-857, 2017 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-28581483
8.
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Bioorg Med Chem
; 26(1): 25-36, 2018 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29170024
9.
Small-molecule modulators of PXR and CAR.
Biochim Biophys Acta
; 1859(9): 1141-1154, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-26921498
10.
Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor.
Drug Metab Dispos
; 44(11): 1759-1770, 2016 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27519550
11.
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR.
Nat Commun
; 15(1): 4054, 2024 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38744881
12.
Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.
Toxicol Appl Pharmacol
; 272(1): 96-107, 2013 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23707768
13.
Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors.
ACS Med Chem Lett
; 14(10): 1441-1447, 2023 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37849548
14.
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.
Eur J Med Chem
; 251: 115246, 2023 May 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36898329
15.
Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation.
J Biol Chem
; 286(44): 38264-38274, 2011 Nov 04.
Artigo
Inglês
| MEDLINE | ID: mdl-21903592
16.
Design and Optimization of 1H-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR.
J Med Chem
; 65(24): 16829-16859, 2022 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-36480704
17.
Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactions.
J Am Chem Soc
; 133(4): 676-9, 2011 Feb 02.
Artigo
Inglês
| MEDLINE | ID: mdl-21171592
18.
Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors.
Bioorg Med Chem Lett
; 21(23): 7151-4, 2011 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22001086
19.
Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes.
Bioorg Med Chem Lett
; 21(11): 3395-8, 2011 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21524572
20.
Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70.
J Med Chem
; 64(3): 1733-1761, 2021 02 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33497575