RESUMO
In 139 patients with verified gastric cancer, the infiltration of the postoperative material with CD8+ cells was analyzed. Automated morphometric analysis of immunostained slides was performed separately in different specimen sites (tumor center, invasive edge, and peritumoral mucosa). The mean area of infiltrating CD8+ cells in the tumor center and in the invasive edge was not predictive, while in the peritumoral mucosa it provided a new negative predictive factor (hazard ratio 2.10; confidence interval 0.87-4.92, Cox regression) reliably associated with the TNM stage (hazard ratio 1.91; confidence interval 0.91-4.61, Cox regression).
Assuntos
Carcinoma , Neoplasias Gástricas , Humanos , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/patologia , Prognóstico , Linfócitos do Interstício Tumoral/patologia , Linfócitos T CD8-Positivos/patologia , Carcinoma/patologiaRESUMO
It is presented the treatment results of abdominal and intraabdominal desmoid fibromas. Group of abdominal localization included 19 patients. 15 of them had primary tumors, 4 - recurrent tumors after surgical treatment. Radical (R0) operations were performed in all cases. Tumor removal was associated with plastic of abdominal wall by synthetic implant in 17 patients. Wide excision of surrounding tissues and musculo-aponeurotic layer of anterior abdominal wall allows to achieve long-term disease-free period. There weren't recurrent symptoms in terms from 4 to 60 months of observation. The second group included 28 patients with intraabdominal desmoid fibromas. Operations were performed in 11 (35.2%) patients including 3 cases of reoperations. There were 14 operations. Radical (R0) volume was applied in 11 (78.6%) operations, cytoreductive (R2) volume - in 1 (7%) operation. Explorative laparotomy was used in 3 (21.4%) cases because of involvement of mesenteric vessels. Combined treatment was performed in 4 (14.3%) patients. 14 (50%) patients received conservative therapy because of unresectable tumor including chemo-, hormone- and radiotherapy. Operated patients were under observation in terms from 11 to 156 months, median was 63.2 months. Recurrence developed in 4 of 10 (40%) patients after R0-surgery. Cytoreductive (R1/R2) volume is admitted for intraabdominal desmoid fibromas. But even in case of unresectable process and explorative intervention stabilization and regression of tumor is possible by means of chemo-, hormone- and radiotherapy in different combination. It allows to preserve a good life quality.
Assuntos
Cavidade Abdominal , Procedimentos Cirúrgicos de Citorredução , Dissecação , Fibromatose Abdominal , Laparotomia , Recidiva Local de Neoplasia , Complicações Pós-Operatórias/prevenção & controle , Cavidade Abdominal/patologia , Cavidade Abdominal/cirurgia , Parede Abdominal/patologia , Parede Abdominal/cirurgia , Técnicas de Fechamento de Ferimentos Abdominais , Adulto , Terapia Combinada , Procedimentos Cirúrgicos de Citorredução/efeitos adversos , Procedimentos Cirúrgicos de Citorredução/métodos , Dissecação/efeitos adversos , Dissecação/métodos , Feminino , Fibromatose Abdominal/patologia , Fibromatose Abdominal/cirurgia , Humanos , Laparotomia/efeitos adversos , Laparotomia/métodos , Masculino , Moscou , Complicações Pós-Operatórias/classificação , Estudos Retrospectivos , Resultado do TratamentoRESUMO
The experimental simulation of ovary hyperstimulation syndrome (OHSS) in test murine by administration with several dozes of exogenous gonadotropic hormones has been performed. It has been shown that mouse ovary hormone stimulation leads to manifestation of all OHSS symptoms: ovary swelling and hyperemia, injury of their structure, cystic corpus luteum formation, hemorrhagic follicles, folliculogenesis disturbance, oocyte and embryo morphology injury. The degree of OHSS symptom manifestation depends on hormone doze. On the third day after human chorionic gonadotropin administration all OHSS symptoms take place as an evidence of this syndrome prolonged character.